INT276955

Context Info Confidence 0.14 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.76 Pain Relevance 0.04

cytoplasm (Tlr2, Il13) extracellular space (Il13) signal transduction (Tlr2) extracellular region (Il13) plasma membrane (Tlr2) intracellular (Tlr2)

Tlr2 (Mus musculus) Il13 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 9 72.08 cytokine 9 5.00 chemokine 5 5.00 Inflammation 4 5.00 agonist 2 5.00 anesthesia 1 5.00 fibrosis 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Yersinia Infection 1 99.12 Cancer 81 87.08 Metastasis 46 60.48 Brain Tumor 1 53.64 Immunotherapy Of Cancer 2 51.60 Lewis Lung Carcinoma 1 43.96 Skin Cancer 8 18.00 Death 7 5.00 Experimental Melanoma 5 5.00 INFLAMMATION 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thirdly, TLR2 mediated the HSP60-stimulated the expression of Stat3-controled suppressive factors, such as IL-10, IL-13, TGF-?

TLR2 Positive_regulation (mediated) of Negative_regulation (suppressive) of IL-13

1) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.76 Pain Relevance 0.04

General Comments

This test has worked.