INT276988

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Revision as of 11:58, 12 September 2012

Context Info
Confidence 1.1949730300
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in NULL
Documents 11
Total Number 11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr6, Tlr2) plasma membrane (Tlr6, Tlr2) intracellular (Tlr6, Tlr2)
cytoplasm (Tlr2)
Anatomy Mention Frequency
lung 1
Tlr6 (Mus musculus)
Tlr2 (Mus musculus)
Pain Term Frequency Confidence Heat
addiction 2 19.76 Low Low
chemokine 22 16.52 Low Low
Spinal cord 2 5 Very Low Very Low Very Low
Central nervous system 42 5 Very Low Very Low Very Low
Neuropeptide 2 5 Very Low Very Low Very Low
Inflammatory mediators 8 5 Very Low Very Low Very Low
rheumatoid arthritis 3 5 Very Low Very Low Very Low
Substantia nigra 8 5 Very Low Very Low Very Low
antagonist 9 5 Very Low Very Low Very Low
orphanin 2 5 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
American Trypanosomiasis 2 94.72 High High
Hepatitis 2 60.64 Quite High
Pneumonia 10 40.8 Quite Low
Pulmonary Fibrosis 3 27.16 Quite Low
Brain Injury 2 20.72 Low Low
Head Trauma 2 15.44 Low Low
Fibrosis 2 5 Very Low Very Low Very Low
Metastasis 138 5 Very Low Very Low Very Low
Multiple Myeloma 1 5 Very Low Very Low Very Low
Necrosis 10 5 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Event Anatomy Negation Speculation Pain term
Finally, TLR2 heterodimerizes with TLR1 and TLR6, and TLR2 signaling is modulated by other non-TLR receptors such as dectin-1 [47], asioloGM1 [48], and CXCR4 [49].
TLR6 Binding (heterodimerizes) of TLR2
1) Confidence 0.259815360008725 Published 2010 Journal N/A Section N/A Doc Link PMC2816997
Finally, TLR2 heterodimerizes with TLR1 and TLR6, and TLR2 signaling is modulated by other non-TLR receptors such as dectin-1 [47], asioloGM1 [48], and CXCR4 [49].
TLR6 Binding (heterodimerizes) of TLR2
2) Confidence 0.259815360008725 Published 2010 Journal N/A Section N/A Doc Link PMC2816997
Since TLR2 functions via dimerization with TLR1, TLR6, or Dectin-1, respectively [15], we examined the dimerizing partners of TLR2 in these cells and found that TLR2 co-localized with TLR6 or Dectin-1, but not TLR1 (Fig. 1C).
TLR6 Binding (dimerization) of TLR2
3) Confidence 0.235229039066652 Published 2009 Journal N/A Section N/A Doc Link PMC2716531
In the end of this study, Kim et al have reported that TLR2 plays a critical role in the metastasis of Lewis lung carcinoma through an interaction between TLR2/TLR6 dimmer and extracellular matrix proteoglycan versican [23], [24].
TLR6 Binding (interaction) of TLR2 in lung
4) Confidence 0.208683185401742 Published 2009 Journal N/A Section N/A Doc Link PMC2716531
Since TLR2 functions via dimerization with TLR1, TLR6, or Dectin-1, respectively [15], we examined the dimerizing partners of TLR2 in these cells and found that TLR2 co-localized with TLR6 or Dectin-1, but not TLR1 (Fig. 1C).
TLR6 Binding (localized) of TLR2
5) Confidence 0.20059378102381 Published 2009 Journal N/A Section N/A Doc Link PMC2716531
TLR2 can form a complex with TLR1 or TLR6 and respond to lipopeptides from a wide variety of microbes.
TLR6 Binding (complex) of TLR2
6) Confidence 0.0980955904321829 Published 2010 Journal N/A Section N/A Doc Link PMC2913815
TLR2 can form a complex with TLR1 or TLR6 and respond to lipopeptides from a wide variety of microbes.
TLR6 Binding (form) of TLR2
7) Confidence 0.0980955904321829 Published 2010 Journal N/A Section N/A Doc Link PMC2913815
Briefly, TLR2, which works with TLR1 or TLR6, recognizes bacterial components, such as lipopeptide and lipoprotein of gram-positive bacteria; specifically, the heterodimer TLR1/2 which can recognize triacyl lipopeptide, while TLR2/6 recognizes diacyl lipopeptide.TLR7 is documented to recognize RNA, while TLR9-DNA, both microbial and self [89, 90].


TLR6 Binding (works) of TLR2
8) Confidence 0.0765037981262951 Published 2010 Journal N/A Section N/A Doc Link PMC2989704
The resulting TLR1/TLR2 and TLR6/TLR2 complexes recognize distinct ligands, triacyl and diacyl lipoproteins, respectively.
TLR6 Binding (complexes) of TLR2
9) Confidence 0.0761659497393008 Published 2010 Journal N/A Section N/A Doc Link PMC2913855
TLR2 recognizes its ligands by forming a heterodimer with either TLR1 or TLR6.
TLR6 Binding (recognizes) of TLR2
10) Confidence 0.0732134494404178 Published 2010 Journal N/A Section N/A Doc Link PMC2913855
TLR2 can form heterodimers with TLR1 and TLR6, thereby improving the recognition of the target lipoteichoic acids [63].
TLR6 Binding (heterodimers) of TLR2
11) Confidence 0.0180389244046499 Published 2010 Journal N/A Section N/A Doc Link PMC3003996

General Comments

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