INT276988

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{| style="color: black; background-color: white;" class="wikitable"
+
{| style="color: black; background-color: white;"
| colspan="3" style="color: black; background-color: white; vertical-align: top"|
+
| style="color: black; background-color: white; vertical-align: top"|
 
{| cellpadding=3 cellspacing=0  
 
{| cellpadding=3 cellspacing=0  
 
|-
 
|-
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|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.1949730300
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.26
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2009
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2009|2009]]
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated
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|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Reported most in
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Reported most in
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| NULL
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| Body
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Documents
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Documents
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Total Number
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Total Number
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 11
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 11
 +
|-
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 4.89
 +
|-
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 0.79
 
|-
 
|-
 
|}
 
|}
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fontcolor=white,
 
fontcolor=white,
 
label="Binding",
 
label="Binding",
URL=Binding
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=E:Binding"
 
];
 
];
 
node2
 
node2
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fontcolor=white,
 
fontcolor=white,
 
label="Tlr6",
 
label="Tlr6",
URL="Tlr6"
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=G:21899"
 
];
 
];
 
node3
 
node3
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fontcolor=white,
 
fontcolor=white,
 
label="Tlr2",
 
label="Tlr2",
URL="Tlr2"
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=G:24088"
 
];
 
];
 
subgraph cluster_0 {
 
subgraph cluster_0 {
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{| cellspacing=5 cellpadding=2
 
{| cellspacing=5 cellpadding=2
 
|-
 
|-
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[signal transduction]] ([[Tlr6]], [[Tlr2]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:signal transduction|signal transduction]] ([[G:21899|Tlr6]], [[G:24088|Tlr2]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[plasma membrane]] ([[Tlr6]], [[Tlr2]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:plasma membrane|plasma membrane]] ([[G:21899|Tlr6]], [[G:24088|Tlr2]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[intracellular]] ([[Tlr6]], [[Tlr2]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:intracellular|intracellular]] ([[G:21899|Tlr6]], [[G:24088|Tlr2]])
 
|-
 
|-
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[cytoplasm]] ([[Tlr2]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:cytoplasm|cytoplasm]] ([[G:24088|Tlr2]])
 
|-
 
|-
 
|}
 
|}
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{| cellpadding=3 cellspacing=0  
 
{| cellpadding=3 cellspacing=0  
 
|-
 
|-
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Anatomy Mention
+
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Anatomy Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;" align="center"| Frequency
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;" align="center"| Frequency
 
|-
 
|-
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[anat:100|lung]]
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[A:lung|lung]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|1
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|1
 
|-
 
|-
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|-
 
|-
 
|}
 
|}
 +
 
|-
 
|-
 +
|}
 +
{| cellspacing=2 cellpadding=2
 +
| style="vertical-align: top"|
 +
{| cellspacing=1 cellpadding=5 align=center
 +
|-
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Pain Link
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Relevance
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Inflammation|Inflammation]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 70
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 95.68
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:agonist|agonist]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 40
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 93.16
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:cytokine|cytokine]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 62
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 92.68
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:tolerance|tolerance]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 31
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 65.32
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Inflammatory response|Inflammatory response]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 36
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 64.28
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:ischemia|ischemia]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 44
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 58.64
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:chemokine|chemokine]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 22
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 40.52
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Quite Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:fibrosis|fibrosis]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 33.36
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Quite Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Central nervous system|Central nervous system]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 42
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 20.72
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:addiction|addiction]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 19.96
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 +
|-
 +
 +
|}
 +
|
 +
| style="vertical-align: top"|
 +
{| cellspacing=1 cellpadding=5 align=center
 +
|-
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Disease Link
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Relevance
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Metastasis|Metastasis]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 138
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Lewis Lung Carcinoma|Lewis Lung Carcinoma]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Injury|Injury]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 125
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 99.32
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Cancer|Cancer]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 255
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.28
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:INFLAMMATION|INFLAMMATION]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 89
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 95.68
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:American Trypanosomiasis|American Trypanosomiasis]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 94.72
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Hemorrhagic Shock|Hemorrhagic Shock]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 66
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 91.76
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Bacterial Respiratory Disease|Bacterial Respiratory Disease]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 7
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 86.24
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Brain Tumor|Brain Tumor]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 84.80
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Skin Cancer|Skin Cancer]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 24
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 76.76
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
|}
 
|}
 
|}
  
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| style="color: black; background:white; white-space:wrap;"| Key:
 
| style="color: black; background:white; white-space:wrap;"| Key:
 
| style="color: black; background:#FFFF00; border: 1px solid lightgray; white-space:wrap;"| Protein
 
| style="color: black; background:#FFFF00; border: 1px solid lightgray; white-space:wrap;"| Protein
 +
| style="color: black; background:#ADFF2F; border: 1px solid lightgray; white-space:wrap;"| Mutation
 
| style="color: black; background:#B0E0E6; border: 1px solid lightgray; white-space:wrap;"| Event
 
| style="color: black; background:#B0E0E6; border: 1px solid lightgray; white-space:wrap;"| Event
 
| style="color: black; background:#FFDEAD; border: 1px solid lightgray; white-space:wrap;"| Anatomy
 
| style="color: black; background:#FFDEAD; border: 1px solid lightgray; white-space:wrap;"| Anatomy
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| style="color: black; background:#D3D3D3; border: 1px solid lightgray; white-space:wrap;"| Speculation
 
| style="color: black; background:#D3D3D3; border: 1px solid lightgray; white-space:wrap;"| Speculation
 
| style="color: black; background:#FFA07A; border: 1px solid lightgray; white-space:wrap;"| Pain term
 
| style="color: black; background:#FFA07A; border: 1px solid lightgray; white-space:wrap;"| Pain term
 +
| style="color: black; background:#FFA07A; border: 1px solid lightgray; white-space:wrap;"| Disease term
 
|-
 
|-
 
|}
 
|}
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{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TLR6'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">heterodimerizes</span>) of <span style="color:#800000">'''TLR2'''</span>
+
|  [[G:21899|<span style="color:#800000">'''TLR6'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">heterodimerizes</span>) of [[G:24088|<span style="color:#800000">'''TLR2'''</span>]]
 
|-
 
|-
 
|}
 
|}
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! style="color: black; background:white; white-space:nowrap;"| 1)
 
! style="color: black; background:white; white-space:nowrap;"| 1)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.259815360008725
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.26
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS ONE|PLoS ONE]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2816997 PMC2816997]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2816997 PMC2816997]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.47
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.17
 
|}
 
|}
 
|-
 
|-
Line 147: Line 282:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TLR6'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">heterodimerizes</span>) of <span style="color:#800000">'''TLR2'''</span>
+
|  [[G:21899|<span style="color:#800000">'''TLR6'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">heterodimerizes</span>) of [[G:24088|<span style="color:#800000">'''TLR2'''</span>]]
 
|-
 
|-
 
|}
 
|}
Line 156: Line 291:
 
! style="color: black; background:white; white-space:nowrap;"| 2)
 
! style="color: black; background:white; white-space:nowrap;"| 2)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.259815360008725
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.26
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS ONE|PLoS ONE]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2816997 PMC2816997]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2816997 PMC2816997]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.48
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.16
 
|}
 
|}
 
|-
 
|-
Line 174: Line 313:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TLR6'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">dimerization</span>) of <span style="color:#800000">'''TLR2'''</span>
+
|  [[G:21899|<span style="color:#800000">'''TLR6'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">dimerization</span>) of [[G:24088|<span style="color:#800000">'''TLR2'''</span>]]
 
|-
 
|-
 
|}
 
|}
Line 183: Line 322:
 
! style="color: black; background:white; white-space:nowrap;"| 3)
 
! style="color: black; background:white; white-space:nowrap;"| 3)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.235229039066652
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.24
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2009
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2009|2009]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS ONE|PLoS ONE]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2716531 PMC2716531]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2716531 PMC2716531]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.30
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.08
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| In the end of this study, Kim et al have reported that <span style="background-color:#FFFF00">TLR2</span> plays a critical role in the metastasis of Lewis <span style="background-color:#FFDEAD">lung</span> carcinoma through an <span style="background-color:#B0E0E6">interaction</span> between TLR2/<span style="background-color:#FFFF00">TLR6</span> dimmer and extracellular matrix proteoglycan versican [23], [24].  
+
| In the end of this study, Kim et al have reported that <span style="background-color:#FFFF00">TLR2</span> plays a critical role in the <span style="background-color:#FFA07A">metastasis</span> of <span style="background-color:#FFA07A">Lewis lung carcinoma</span> through an <span style="background-color:#B0E0E6">interaction</span> between TLR2/<span style="background-color:#FFFF00">TLR6</span> dimmer and extracellular matrix proteoglycan versican [23], [24].  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TLR6'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">interaction</span>) of <span style="color:#800000">'''TLR2'''</span> in <span style="color:#808000">lung</span>
+
|  [[G:21899|<span style="color:#800000">'''TLR6'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">interaction</span>) of [[G:24088|<span style="color:#800000">'''TLR2'''</span>]] in [[A:lung|<span style="color:#808000">lung</span>]] associated with <span style="color:#FF0000">'''lewis lung carcinoma'''</span> and <span style="color:#FF0000">'''metastasis'''</span>
 
|-
 
|-
 
|}
 
|}
Line 210: Line 353:
 
! style="color: black; background:white; white-space:nowrap;"| 4)
 
! style="color: black; background:white; white-space:nowrap;"| 4)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.208683185401742
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.21
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2009
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2009|2009]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS ONE|PLoS ONE]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2716531 PMC2716531]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2716531 PMC2716531]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.23
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.03
 
|}
 
|}
 
|-
 
|-
Line 228: Line 375:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TLR6'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">localized</span>) of <span style="color:#800000">'''TLR2'''</span>
+
|  [[G:21899|<span style="color:#800000">'''TLR6'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">localized</span>) of [[G:24088|<span style="color:#800000">'''TLR2'''</span>]]
 
|-
 
|-
 
|}
 
|}
Line 237: Line 384:
 
! style="color: black; background:white; white-space:nowrap;"| 5)
 
! style="color: black; background:white; white-space:nowrap;"| 5)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.20059378102381
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.20
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2009
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2009|2009]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS ONE|PLoS ONE]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2716531 PMC2716531]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2716531 PMC2716531]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.28
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.07
 
|}
 
|}
 
|-
 
|-
Line 255: Line 406:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TLR6'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">complex</span>) of <span style="color:#800000">'''TLR2'''</span>
+
|  [[G:21899|<span style="color:#800000">'''TLR6'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">complex</span>) of [[G:24088|<span style="color:#800000">'''TLR2'''</span>]]
 
|-
 
|-
 
|}
 
|}
Line 264: Line 415:
 
! style="color: black; background:white; white-space:nowrap;"| 6)
 
! style="color: black; background:white; white-space:nowrap;"| 6)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.0980955904321829
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.10
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Mediators of Inflammation|Mediators of Inflammation]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2913815 PMC2913815]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2913815 PMC2913815]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.13
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.07
 
|}
 
|}
 
|-
 
|-
Line 282: Line 437:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TLR6'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">form</span>) of <span style="color:#800000">'''TLR2'''</span>
+
|  [[G:21899|<span style="color:#800000">'''TLR6'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">form</span>) of [[G:24088|<span style="color:#800000">'''TLR2'''</span>]]
 
|-
 
|-
 
|}
 
|}
Line 291: Line 446:
 
! style="color: black; background:white; white-space:nowrap;"| 7)
 
! style="color: black; background:white; white-space:nowrap;"| 7)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.0980955904321829
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.10
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Mediators of Inflammation|Mediators of Inflammation]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2913815 PMC2913815]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2913815 PMC2913815]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.13
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.07
 
|}
 
|}
 
|-
 
|-
Line 312: Line 471:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TLR6'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">works</span>) of <span style="color:#800000">'''TLR2'''</span>
+
|  [[G:21899|<span style="color:#800000">'''TLR6'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">works</span>) of [[G:24088|<span style="color:#800000">'''TLR2'''</span>]]
 
|-
 
|-
 
|}
 
|}
Line 321: Line 480:
 
! style="color: black; background:white; white-space:nowrap;"| 8)
 
! style="color: black; background:white; white-space:nowrap;"| 8)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.0765037981262951
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.08
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Autoimmune Diseases|Autoimmune Diseases]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2989704 PMC2989704]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2989704 PMC2989704]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.18
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.03
 
|}
 
|}
 
|-
 
|-
Line 340: Line 503:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TLR6'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">complexes</span>) of <span style="color:#800000">'''TLR2'''</span>
+
|  [[G:21899|<span style="color:#800000">'''TLR6'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">complexes</span>) of [[G:24088|<span style="color:#800000">'''TLR2'''</span>]]
 
|-
 
|-
 
|}
 
|}
Line 349: Line 512:
 
! style="color: black; background:white; white-space:nowrap;"| 9)
 
! style="color: black; background:white; white-space:nowrap;"| 9)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.0761659497393008
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.08
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Mediators of Inflammation|Mediators of Inflammation]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2913855 PMC2913855]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2913855 PMC2913855]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.79
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.05
 
|}
 
|}
 
|-
 
|-
Line 367: Line 534:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TLR6'''</span> <span style="color:#000080">'''Binding'''</span> (<span style="color:#000080">recognizes</span>) of <span style="color:#800000">'''TLR2'''</span>
+
|  [[G:21899|<span style="color:#800000">'''TLR6'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">recognizes</span>) of [[G:24088|<span style="color:#800000">'''TLR2'''</span>]]
 
|-
 
|-
 
|}
 
|}
Line 376: Line 543:
 
! style="color: black; background:white; white-space:nowrap;"| 10)
 
! style="color: black; background:white; white-space:nowrap;"| 10)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.0732134494404178
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.07
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Mediators of Inflammation|Mediators of Inflammation]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2913855 PMC2913855]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2913855 PMC2913855]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.81
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.06
 +
|}
 +
|-
 +
|}
 +
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 +
| <span style="background-color:#FFFF00">TLR2</span> can form <span style="background-color:#B0E0E6">heterodimers</span> with TLR1 and <span style="background-color:#FFFF00">TLR6</span>, thereby improving the recognition of the target lipoteichoic acids [63].
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
|  [[G:21899|<span style="color:#800000">'''TLR6'''</span>]] [[E:Binding|<span style="color:#000080">'''Binding'''</span>]] (<span style="color:#000080">heterodimers</span>) of [[G:24088|<span style="color:#800000">'''TLR2'''</span>]]
 +
|-
 +
|}
 +
|-
 +
|
 +
{| cellpadding=4 cellspacing=2
 +
|-
 +
! style="color: black; background:white; white-space:nowrap;"| 11)
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.02
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:International Journal of Inflammation|International Journal of Inflammation]]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC3003996 PMC3003996]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.09
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 
|}
 
|}
 
|-
 
|-

Latest revision as of 23:42, 20 September 2012

Context Info
Confidence 0.26
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.89
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr6, Tlr2) plasma membrane (Tlr6, Tlr2) intracellular (Tlr6, Tlr2)
cytoplasm (Tlr2)
Anatomy Link Frequency
lung 1
Tlr6 (Mus musculus)
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 70 95.68 Very High Very High Very High
agonist 40 93.16 High High
cytokine 62 92.68 High High
tolerance 31 65.32 Quite High
Inflammatory response 36 64.28 Quite High
ischemia 44 58.64 Quite High
chemokine 22 40.52 Quite Low
fibrosis 5 33.36 Quite Low
Central nervous system 42 20.72 Low Low
addiction 2 19.96 Low Low
Disease Link Frequency Relevance Heat
Metastasis 138 100.00 Very High Very High Very High
Lewis Lung Carcinoma 3 100.00 Very High Very High Very High
Injury 125 99.32 Very High Very High Very High
Cancer 255 97.28 Very High Very High Very High
INFLAMMATION 89 95.68 Very High Very High Very High
American Trypanosomiasis 2 94.72 High High
Hemorrhagic Shock 66 91.76 High High
Bacterial Respiratory Disease 7 86.24 High High
Brain Tumor 3 84.80 Quite High
Skin Cancer 24 76.76 Quite High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, TLR2 heterodimerizes with TLR1 and TLR6, and TLR2 signaling is modulated by other non-TLR receptors such as dectin-1 [47], asioloGM1 [48], and CXCR4 [49].
TLR6 Binding (heterodimerizes) of TLR2
1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.47 Pain Relevance 0.17
Finally, TLR2 heterodimerizes with TLR1 and TLR6, and TLR2 signaling is modulated by other non-TLR receptors such as dectin-1 [47], asioloGM1 [48], and CXCR4 [49].
TLR6 Binding (heterodimerizes) of TLR2
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.48 Pain Relevance 0.16
Since TLR2 functions via dimerization with TLR1, TLR6, or Dectin-1, respectively [15], we examined the dimerizing partners of TLR2 in these cells and found that TLR2 co-localized with TLR6 or Dectin-1, but not TLR1 (Fig. 1C).
TLR6 Binding (dimerization) of TLR2
3) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.30 Pain Relevance 0.08
In the end of this study, Kim et al have reported that TLR2 plays a critical role in the metastasis of Lewis lung carcinoma through an interaction between TLR2/TLR6 dimmer and extracellular matrix proteoglycan versican [23], [24].
TLR6 Binding (interaction) of TLR2 in lung associated with lewis lung carcinoma and metastasis
4) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.23 Pain Relevance 0.03
Since TLR2 functions via dimerization with TLR1, TLR6, or Dectin-1, respectively [15], we examined the dimerizing partners of TLR2 in these cells and found that TLR2 co-localized with TLR6 or Dectin-1, but not TLR1 (Fig. 1C).
TLR6 Binding (localized) of TLR2
5) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.28 Pain Relevance 0.07
TLR2 can form a complex with TLR1 or TLR6 and respond to lipopeptides from a wide variety of microbes.
TLR6 Binding (complex) of TLR2
6) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.13 Pain Relevance 0.07
TLR2 can form a complex with TLR1 or TLR6 and respond to lipopeptides from a wide variety of microbes.
TLR6 Binding (form) of TLR2
7) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.13 Pain Relevance 0.07
Briefly, TLR2, which works with TLR1 or TLR6, recognizes bacterial components, such as lipopeptide and lipoprotein of gram-positive bacteria; specifically, the heterodimer TLR1/2 which can recognize triacyl lipopeptide, while TLR2/6 recognizes diacyl lipopeptide.TLR7 is documented to recognize RNA, while TLR9-DNA, both microbial and self [89, 90].


TLR6 Binding (works) of TLR2
8) Confidence 0.08 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.18 Pain Relevance 0.03
The resulting TLR1/TLR2 and TLR6/TLR2 complexes recognize distinct ligands, triacyl and diacyl lipoproteins, respectively.
TLR6 Binding (complexes) of TLR2
9) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.79 Pain Relevance 0.05
TLR2 recognizes its ligands by forming a heterodimer with either TLR1 or TLR6.
TLR6 Binding (recognizes) of TLR2
10) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.81 Pain Relevance 0.06
TLR2 can form heterodimers with TLR1 and TLR6, thereby improving the recognition of the target lipoteichoic acids [63].
TLR6 Binding (heterodimers) of TLR2
11) Confidence 0.02 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.09 Pain Relevance 0

[edit] General Comments

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