INT276988

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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.259815360008725
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.235229039066652
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.208683185401742
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.0980955904321829
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.0980955904321829
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.0765037981262951
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.0761659497393008
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.0732134494404178
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.0732134494404178

Revision as of 20:55, 22 August 2012

Context Info
Confidence 1.1949730300
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in NULL
Documents 11
Total Number 11

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signal transduction (Tlr6, Tlr2) plasma membrane (Tlr6, Tlr2) intracellular (Tlr6, Tlr2)
cytoplasm (Tlr2)
Anatomy Mention Frequency
lung 1
Tlr6 (Mus musculus)
Tlr2 (Mus musculus)

Sentences Mentioned In

Key: Protein Event Anatomy Negation Speculation Pain term
Finally, TLR2 heterodimerizes with TLR1 and TLR6, and TLR2 signaling is modulated by other non-TLR receptors such as dectin-1 [47], asioloGM1 [48], and CXCR4 [49].
TLR6 Binding (heterodimerizes) of TLR2
1) Confidence 0.259815360008725 Published 2010 Journal N/A Section N/A Doc Link PMC2816997
Finally, TLR2 heterodimerizes with TLR1 and TLR6, and TLR2 signaling is modulated by other non-TLR receptors such as dectin-1 [47], asioloGM1 [48], and CXCR4 [49].
TLR6 Binding (heterodimerizes) of TLR2
2) Confidence 0.259815360008725 Published 2010 Journal N/A Section N/A Doc Link PMC2816997
Since TLR2 functions via dimerization with TLR1, TLR6, or Dectin-1, respectively [15], we examined the dimerizing partners of TLR2 in these cells and found that TLR2 co-localized with TLR6 or Dectin-1, but not TLR1 (Fig. 1C).
TLR6 Binding (dimerization) of TLR2
3) Confidence 0.235229039066652 Published 2009 Journal N/A Section N/A Doc Link PMC2716531
In the end of this study, Kim et al have reported that TLR2 plays a critical role in the metastasis of Lewis lung carcinoma through an interaction between TLR2/TLR6 dimmer and extracellular matrix proteoglycan versican [23], [24].
TLR6 Binding (interaction) of TLR2 in lung
4) Confidence 0.208683185401742 Published 2009 Journal N/A Section N/A Doc Link PMC2716531
Since TLR2 functions via dimerization with TLR1, TLR6, or Dectin-1, respectively [15], we examined the dimerizing partners of TLR2 in these cells and found that TLR2 co-localized with TLR6 or Dectin-1, but not TLR1 (Fig. 1C).
TLR6 Binding (localized) of TLR2
5) Confidence 0.20059378102381 Published 2009 Journal N/A Section N/A Doc Link PMC2716531
TLR2 can form a complex with TLR1 or TLR6 and respond to lipopeptides from a wide variety of microbes.
TLR6 Binding (complex) of TLR2
6) Confidence 0.0980955904321829 Published 2010 Journal N/A Section N/A Doc Link PMC2913815
TLR2 can form a complex with TLR1 or TLR6 and respond to lipopeptides from a wide variety of microbes.
TLR6 Binding (form) of TLR2
7) Confidence 0.0980955904321829 Published 2010 Journal N/A Section N/A Doc Link PMC2913815
Briefly, TLR2, which works with TLR1 or TLR6, recognizes bacterial components, such as lipopeptide and lipoprotein of gram-positive bacteria; specifically, the heterodimer TLR1/2 which can recognize triacyl lipopeptide, while TLR2/6 recognizes diacyl lipopeptide.TLR7 is documented to recognize RNA, while TLR9-DNA, both microbial and self [89, 90].


TLR6 Binding (works) of TLR2
8) Confidence 0.0765037981262951 Published 2010 Journal N/A Section N/A Doc Link PMC2989704
The resulting TLR1/TLR2 and TLR6/TLR2 complexes recognize distinct ligands, triacyl and diacyl lipoproteins, respectively.
TLR6 Binding (complexes) of TLR2
9) Confidence 0.0761659497393008 Published 2010 Journal N/A Section N/A Doc Link PMC2913855
TLR2 recognizes its ligands by forming a heterodimer with either TLR1 or TLR6.
TLR6 Binding (recognizes) of TLR2
10) Confidence 0.0732134494404178 Published 2010 Journal N/A Section N/A Doc Link PMC2913855

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