INT27703

Context Info Confidence 0.52 First Reported 1989 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 2.08 Pain Relevance 0.26

Pol1 (Mus musculus)

Pain Link Frequency Relevance Heat neuralgia 1 83.68 Pain 1 62.96 Post herpetic neuralgia 3 60.16

Disease Link Frequency Relevance Heat Herpes Zoster 20 99.14 Infection 1 90.80 Neuralgia 4 83.68 Acquired Immune Deficiency Syndrome Or Hiv Infection 1 80.96 Cancer 1 71.32 Syndrome 1 70.20 Pain 1 62.96 Herpes Simplex Virus Infection 1 59.76 Vomiting 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Among the antiviral drugs available at present, aciclovir has proved especially useful, acting as an inhibitor of viral DNA polymerase.

Negative_regulation (inhibitor) of viral DNA polymerase

1) Confidence 0.52 Published 1989 Journal Z. Hautkr. Section Abstract Doc Link 2660444 Disease Relevance 1.30 Pain Relevance 0.08

It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage.

Negative_regulation (inhibition) of viral DNA polymerase associated with herpes zoster

2) Confidence 0.52 Published 2004 Journal Drugs Section Abstract Doc Link 15341504 Disease Relevance 0.78 Pain Relevance 0.18

General Comments

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