INT277268

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 2.47
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a11) cytoplasm (Slc6a11)
Anatomy Link Frequency
brain 2
SK-N-SH 2
mossy fiber 1
Slc6a11 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 135 100.00 Very High Very High Very High
imagery 150 99.30 Very High Very High Very High
GABAergic 150 99.04 Very High Very High Very High
interneuron 15 5.00 Very Low Very Low Very Low
anesthesia 15 5.00 Very Low Very Low Very Low
medulla 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Movement Disorders 30 98.96 Very High Very High Very High
Neuroblastoma 15 96.56 Very High Very High Very High
Urological Neuroanatomy 15 96.32 Very High Very High Very High
Targeted Disruption 300 93.60 High High
Sprains And Strains 30 92.32 High High
Peripheral Arterial Disease 60 87.44 High High
Disease 165 81.28 Quite High
Frailty 315 78.52 Quite High
Spinocerebellar Ataxia Type 2 75 75.00 Quite High
Neurological Disease 15 62.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo optical imaging studies in SCA8 mice confirm that Gabt4 upregulation is associated with the predicted loss of GABAergic inhibition within the granular cell layer.
Positive_regulation (upregulation) of Gabt4 associated with gabaergic and imagery
1) Confidence 0.67 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2719092 Disease Relevance 0.21 Pain Relevance 0.15
exon 7 transcripts which prevent their detection or if Gabt4 upregulation in the mouse occurs via another mechanism.


Positive_regulation (upregulation) of Gabt4
2) Confidence 0.67 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.14 Pain Relevance 0
Additional studies are also required to directly test the hypothesis that GABT4 upregulation causes the decrease in GABAergic inhibition seen in our SCA8 BAC-EXP mice.
Positive_regulation (upregulation) of GABT4 associated with gabaergic
3) Confidence 0.67 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.21 Pain Relevance 0.05
We show that overexpression of CUGBP1 in human SK-N-SH cells, or depletion of MBNL1, result in an upregulation of GABT4 that mimics the in vivo changes in steady state levels caused by CUGexp transcripts.
Positive_regulation (upregulation) of GABT4 in SK-N-SH
4) Confidence 0.67 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.07 Pain Relevance 0.08
To test directly if increases in GABT4 are induced by SCA8 CUGexp or CAGexp transcripts, we examined their effects in human neuroblastoma SK-N-SH cells.
Positive_regulation (increases) of GABT4 in SK-N-SH associated with neuroblastoma
5) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.15 Pain Relevance 0
A similar trend of increased GABT4 protein was also seen in SCA8 and fetal brain compared to adult control or DM1 tissue (Figure 5B).
Positive_regulation (increased) of GABT4 protein in brain
6) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.15 Pain Relevance 0.03
Preferential exon 7 inclusion was also seen in control human fetal autopsy tissue but not in adult DM1 tissue and is correlated with the increases in GABT4 RNA and protein seen in SCA8 adult and control fetal brain (Figure 5).
Positive_regulation (increases) of GABT4 in brain
7) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.14 Pain Relevance 0
3) showed increased GABT4 transcripts levels compared to adult control (p<0.01) (Figure 5A) and similar levels to those found in fetal tissue.
Positive_regulation (increased) of GABT4
8) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.16 Pain Relevance 0.04
Because the clearance of synaptically released GABA in the granular layer is predominately mediated by Gabt4, up-regulation of Gabt4 would be expected to reduce this Golgi mediated inhibition and enhance the responses to mossy fiber input.
Positive_regulation (up-regulation) of Gabt4 in mossy fiber associated with gaba
9) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.17 Pain Relevance 0.29
Cells expressing SCA8 CUGexp transcripts show significant increases in GABT4 RNA levels by qRT-PCR relative to untransfected cells (p?
Positive_regulation (increases) of GABT4
10) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.09 Pain Relevance 0
Upregulation of GABA-A Transporter 4 (Gabt4) and Functional Granular Cell Layer Changes in SCA8 Mice
Positive_regulation (Upregulation) of Gabt4 associated with gaba
11) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0 Pain Relevance 0.26
Similar to humans, Gabt4 is also up-regulated in the SCA8 BAC-Exp and Mbnl1?
Positive_regulation (regulated) of Gabt4
12) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.08 Pain Relevance 0
GABT4 upregulation in human SCA8 autopsy tissue and cell culture studies supports a model in which GABT4 levels are regulated by alternative splicing changes and the NMD pathway.
Positive_regulation (upregulation) of GABT4
13) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.27 Pain Relevance 0
The increases in Gabt4 protein were reproducible in both high copy number SCA8 BAC-EXP lines studied (BAC-EXP1 and BAC-EXP2) but more variable in mice from the lower copy number BAC-EXP5 line (data not shown) consistent with the decreased penetrance reported previously in this line.
Positive_regulation (increases) of Gabt4 protein
14) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.36 Pain Relevance 0.16
Consistent with this idea, we found significant increases in cerebellar Gabt4 protein and RNA levels by protein blot (5.36±1.11 fold; p?
Positive_regulation (increases) of Gabt4 protein
15) Confidence 0.39 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.28 Pain Relevance 0.23

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