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Context Info
Confidence 0.08
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.89
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Mtor (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 1 85.88 High High
ischemia 36 50.00 Quite Low
positron emission tomography 37 49.68 Quite Low
imagery 20 5.00 Very Low Very Low Very Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Limbic system 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 59 98.80 Very High Very High Very High
Hepatocellular Cancer 76 96.24 Very High Very High Very High
Cancer 62 94.00 High High
Solid Tumor 1 92.12 High High
Recurrence 1 77.80 Quite High
Disease 58 76.44 Quite High
Dementia 9 71.08 Quite High
Neurodegenerative Disease 9 68.92 Quite High
Infection 6 66.72 Quite High
Hepatitis 1 66.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, this study supports the notion that selective molecular alterations in the autophagy pathway and more specifically in mTor and Atg7 are associated with DLB and ?
Localization (alterations) of mTor associated with parkinson's disease
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.53 Pain Relevance 0
Phosphorylation of the other three sites appears not to be regulated (6, 9). 4E-BP1 is one of the main effectors of mammalian target of rapamycin (mTOR), serine/threonine-protein kinase in the phosphoinositide 3-kinase (PI3-kinase)/Akt (RAC serine/threonine-protein kinase, also named protein kinase B, PKB) signaling pathway that integrates signals from extracellular stimuli, amino acid availability, and oxygen and energy status of the cells (8). 4E-BPs contain a TOR signaling (TOS) motif that binds the mTOR complex 1 (mTORC1) (6). mTORC1 controls the activity of 4E-BP1.
Localization (target) of mTOR
2) Confidence 0.06 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0
Rapamycin (Sirolimus) is an inhibitor of the kinase mammalian target of rapamycin (mTOR) and possesses both antiproliferative and antiangiogenic properties [6].
Localization (target) of mTOR
3) Confidence 0.05 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 1.37 Pain Relevance 0.09

General Comments

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