INT277368

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TFAM, TCF7L2) DNA binding (TFAM, TCF7L2) cell proliferation (TCF7L2)
nucleoplasm (TCF7L2) mitochondrion (TFAM) transcription factor binding (TCF7L2)
TFAM (Homo sapiens)
TCF7L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 83 98.24 Very High Very High Very High
Disease 9 85.60 High High
Insulin Resistance 12 38.20 Quite Low
Obesity 4 20.32 Low Low
Frailty 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Muscle Weakness 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most speculatively, it seems logical that changes in a transcription factor like TCF7L2 will lead to altered expression of other genes and not TCF7L2 itself.
Spec (20854) Regulation (changes) of transcription factor Neg (not) Positive_regulation (lead) of Gene_expression (expression) of TCF7L2
1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.90 Pain Relevance 0

General Comments

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