INT277371

Context Info Confidence 0.72 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.97 Pain Relevance 0

cytosol (LDHB) mitochondrion (LDHB) small molecule metabolic process (LDHB) oxidoreductase activity (LDHB) cytoplasm (LDHB)

LDHB (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 1 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 83 91.08 Insulin Resistance 12 71.76 Frailty 2 68.08 Aging 1 59.80 Appetite Loss 1 59.40 Disease 9 52.04 Obesity 4 40.08 Muscle Weakness 1 27.28 Toxicity 1 5.00 Pressure And Volume Under Development 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since mitochondrial oxidative phosphorylation and LDHB in a way compete for same pool of pyruvate it is also a possibility that decreased levels of LDHB is a compensatory mechanism in response to impaired mitochondrial function as more pyruvate will be available for acetyl Coenzyme A conversion.

Phosphorylation (phosphorylation) of LDHB

1) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.97 Pain Relevance 0

General Comments

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