INT277404

Context Info Confidence 0.62 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.29 Pain Relevance 0

extracellular space (MSTN) growth (MSTN) extracellular region (MSTN) cytoplasm (MSTN)

Anatomy Link Frequency muscle 2 MSTN (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 2 5.00

Disease Link Frequency Relevance Heat Aging 2 98.12 Appetite Loss 2 97.72 Frailty 4 96.60 Diabetes Mellitus 166 94.24 Insulin Resistance 24 92.00 Disease 18 90.36 Muscle Weakness 2 65.60 Obesity 8 5.00 Toxicity 2 5.00 Pressure And Volume Under Development 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Finding GDF8 (myostatin) to be upregulated in healthy first degree relatives in this study suggests that this factor could play an initiating role in the muscle wasting observed in many diabetic patients and potentially in the development of insulin resistance in the prediabetic stage.

Positive_regulation (upregulated) of myostatin in muscle associated with diabetes mellitus, frailty and insulin resistance

1) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 1.14 Pain Relevance 0

Finding GDF8 (myostatin) to be upregulated in healthy first degree relatives in this study suggests that this factor could play an initiating role in the muscle wasting observed in many diabetic patients and potentially in the development of insulin resistance in the prediabetic stage.

Positive_regulation (upregulated) of GDF8 in muscle associated with diabetes mellitus, frailty and insulin resistance

2) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 1.15 Pain Relevance 0

General Comments

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