INT277433

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.60 Pain Relevance 0.13

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf) nucleus (Wibg) cytoplasm (Wibg)

Wibg (Mus musculus) Gdnf (Mus musculus)

Pain Link Frequency Relevance Heat agonist 13 76.00 Intracerebroventricular 1 74.52 midbrain 2 59.96 Spinal cord 1 33.48 antagonist 9 5.00 Substantia nigra 6 5.00 Nerve growth factor 5 5.00 cerebral cortex 4 5.00 Glutamate 3 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Parkinson's Disease 41 98.40 Toxicity 8 98.20 Disease 9 90.72 Parkinsonian Disorders 7 67.32 Targeted Disruption 5 5.00 Hypersensitivity 5 5.00 Sleep Disorders 2 5.00 Death 2 5.00 Ataxia 2 5.00 Gliosis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, the orally active compound, PYM50028, which elevates striatal levels of GDNF, is protective against MPTP toxicity in mice [47], and induction of GDNF is associated with the neurorescue action of rasagilin, a drug of current use in the treatment of Parkinson's disease [48], [49].

PYM50028 Positive_regulation (elevates) of GDNF associated with parkinson's disease, toxicity and disease

1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.60 Pain Relevance 0.13

General Comments

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