INT277701

Context Info Confidence 0.23 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.49 Pain Relevance 0.22

extracellular region (Pdgfb) cytoplasm (Pdgfb)

Anatomy Link Frequency hippocampus 1 Pdgfb (Rattus norvegicus)

Pain Link Frequency Relevance Heat Hippocampus 20 92.76 ischemia 1 78.56 imagery 2 22.16 long-term potentiation 3 5.00 depression 2 5.00 Pain 2 5.00 anesthesia 1 5.00 amygdala 1 5.00

Disease Link Frequency Relevance Heat Stress 64 100.00 Ring Chromosomes 20 99.02 Disease 34 91.04 Cancer 58 89.60 Coma 1 79.48 Superior Vena Cava Syndrome 2 78.64 Cv Unclassified Under Development 1 78.56 Convulsion 4 78.16 Gastrointestinal Stromal Tumor 8 75.36 Metastasis 26 75.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, the finding that SIS significantly decreased acetylated H3 at the promoters of exon I and IV of the BDNF gene indicates that epigenetic mechanisms play a role in the stress-induced changes in distinct BDNF transcripts in the hippocampus.

Localization (decreased) of SIS in hippocampus associated with stress and hippocampus

1) Confidence 0.23 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.92 Pain Relevance 0.22

The karyotype showed two ring chromosomes but there was no involvement of 22q13 where the PDGFB gene is located.

Localization (located) of PDGFB gene associated with ring chromosomes

2) Confidence 0.18 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.34 Pain Relevance 0

In approximately 8% of DFSP the COL1A1-PDGFB fusion is not found suggesting that other genes may be involved in these cases, or that there is a cryptic rearrangement of COL1A1 or PDGFB.

Localization (rearrangement) of PDGFB

3) Confidence 0.15 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.23 Pain Relevance 0

General Comments

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