INT277763

Context Info Confidence 0.03 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 2.34 Pain Relevance 0

transferase activity, transferring glycosyl groups (DPM1) endoplasmic reticulum (DPM1)

Anatomy Link Frequency mast cell 1 DPM1 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 4 5.00 cva 4 5.00 palliative 3 5.00 corticosteroid 2 5.00 fibrosis 2 5.00 Pain 2 5.00 cytokine 1 5.00 Antihistamine 1 5.00 addiction 1 5.00 pruritus 1 5.00

Disease Link Frequency Relevance Heat Myelodysplastic Syndromes 60 100.00 Myeloproliferative Disorder 32 100.00 Myelofibrosis 28 100.00 Myeloid Leukemia 20 100.00 Chronic Myelomonocytic Leukemia 15 100.00 Hypereosinophilic Syndrome 14 100.00 Systemic Mastocytosis 12 100.00 Leukemia 6 100.00 Disease 12 5.00 Eosinophilia 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The MPDs (which include polycythemia vera (PV), essential thrombocythemia (ET), chronic eosinophilic leukemia (CEL), primary myelofibrosis (PMF), chronic myelomonocytic leukemia (CMML), and systemic mast cell disease (SMCD)) exclude chronic myeloid leukemia (CML) because of the pathognomic importance of the BCR-ABL translocation for the diagnosis and treatment of this disorder with imatinib mesylate.

Localization (translocation) of MPDs in mast cell associated with leukemia, myeloid leukemia, myelofibrosis, myeloproliferative disorder, chronic myelomonocytic leukemia, hypereosinophilic syndrome, systemic mastocytosis and myelodysplastic syndromes

1) Confidence 0.03 Published 2007 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2721304 Disease Relevance 2.34 Pain Relevance 0

General Comments

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