INT278196

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Context Info
Confidence 0.76
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 27
Disease Relevance 22.09
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ciita)
Anatomy Link Frequency
T cells 21
mature T cells 2
Ciita (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 378 98.68 Very High Very High Very High
cytokine 243 95.88 Very High Very High Very High
metalloproteinase 27 88.48 High High
Crohn's disease 54 80.04 Quite High
anesthesia 27 23.32 Low Low
Disease Link Frequency Relevance Heat
Colitis 999 99.88 Very High Very High Very High
Targeted Disruption 567 99.34 Very High Very High Very High
INFLAMMATION 351 98.68 Very High Very High Very High
Death 81 97.24 Very High Very High Very High
Disease 243 96.48 Very High Very High Very High
Repression 27 95.20 Very High Very High Very High
Inflammatory Bowel Disease 162 95.12 Very High Very High Very High
Body Weight 189 95.04 Very High Very High Very High
Multiple Sclerosis 54 94.96 High High
Ulcers 27 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, compared with DSS-induced colitis, the over-expression of CIITA in peripheral T cells clearly showed an adverse effect on the inflammation induced by treatment of oxazolone in colons, which is associated with the Th2 bias in CIITA-expressing CD4+ T cells.


Gene_expression (over) of CIITA in T cells associated with colitis and inflammation
1) Confidence 0.76 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.67 Pain Relevance 0.17
Previously, we have shown that the constitutive expression of CIITA in mature T cells suppressed Th1 differentiation both in vitro and in vivo (13).
Gene_expression (expression) of CIITA in mature T cells
2) Confidence 0.76 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.70 Pain Relevance 0.14
In summary, the results shown in current study, when considered in conjunction with our previous results (13), provide additional support for the view that the constitutive expression of CIITA in T cells inhibits Th1 differentiation and promote Th2 differentiation both in vitro and in vivo.



Gene_expression (expression) of CIITA in T cells
3) Confidence 0.76 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.97 Pain Relevance 0.18
Next, we tested whether the over-expression of CIITA in peripheral T cells might influence Th2 immune response in vivo.
Gene_expression (over) of CIITA in T cells
4) Confidence 0.76 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.24 Pain Relevance 0.11
Pathologic changes in colon induced by DSS administration for 7 days were similar in wild type and CIITA Tg mice (Fig. 2), implying that CIITA expression in T cells did not influence the development of DSS-induced colitis.


Gene_expression (expression) of CIITA in T cells associated with colitis
5) Confidence 0.76 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.30 Pain Relevance 0.10
In this study, we showed that forced expression of CIITA in T cells enhanced Th2 immunity, which was confirmed by the increased susceptibility of CIITA-Tg mice to oxazolone-induced colitis, a Th2-mediated IBD model.
Gene_expression (expression) of CIITA in T cells associated with colitis and inflammatory bowel disease
6) Confidence 0.76 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.80 Pain Relevance 0.10
, STAT-1 triggers CIITA expression through interferon-?
Gene_expression (expression) of CIITA
7) Confidence 0.76 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.09 Pain Relevance 0
As we expected, oxazolone-induced colonic inflammation was aggravated in CIITA-Tg mice (Fig. 3, 4), confirming that the CIITA expression in CD4+ T cells tends to bias CD4+ T cell response into Th2.
Gene_expression (expression) of CIITA in T cell associated with inflammation
8) Confidence 0.76 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.33 Pain Relevance 0.23
Based on our results, CIITA expression in T cells did not have any influence on the DSS-induced innate immunity, acute colonic inflammation, resulting in similar progression of the disease both in CIITA Tg and B6 wild type mice.
Gene_expression (expression) of CIITA in T cells associated with inflammation and disease
9) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.34 Pain Relevance 0.11
These data predict that the over-expression of CIITA in T cells should lead to the suppressed Th2 differentiation and an enhanced Th1 differentiation of the CIITA-Tg cells upon activation.
Gene_expression (expression) of CIITA in T cells
10) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.74 Pain Relevance 0
Otten et al. reported that constitutive expression of CIITA in all organs including T cells led to Th2 bias during Th activation and differentiation (14).
Gene_expression (expression) of CIITA in T cells
11) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.64 Pain Relevance 0.08
To determine whether CIITA could indeed play a role in promotion of Th2 response in vivo, we induced experimental colitis with oxazolone using Dlck-CIITA-transgenic (CIITA Tg) mice with restricted expression of CIITA gene in T cells.
Gene_expression (expression) of CIITA in T cells associated with targeted disruption and colitis
12) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.21 Pain Relevance 0.16
In this study, we investigated the influence of constitutive expression of CIITA in T cells on Th2 immune response in vivo using murine experimental colitis model.
Gene_expression (expression) of CIITA in T cells associated with colitis
13) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2721999 Disease Relevance 0.79 Pain Relevance 0.05
All together, it could be suggested that overexpression of CIITA in T cells inhibits Th1 differentiation both in vivo and in vitro.
Gene_expression (overexpression) of CIITA in T cells
14) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.90 Pain Relevance 0.12
In current study, we evaluated the effect of CIITA expression in mature CD4+ T cells on innate and Th2 immune response in vivo using DSS- or oxazolone-induced colitis model.
Gene_expression (expression) of CIITA in T cells associated with colitis
15) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.91 Pain Relevance 0.03
However, our previous results obtained from CIITA-transgenic mice (Dlck-CIITA Tg) were contradictory to the previous ones, in that CD4+ T cells from the Dlck-CIITA Tg mice, in which the CIITA expression is restricted to peripheral T cells, exhibited a low level of IFN-?
Gene_expression (expression) of CIITA in T cells associated with targeted disruption
16) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.41 Pain Relevance 0.07
First, we investigated the effect of CIITA expression in T cells on the course of development of DSS-induced acute colitis.
Gene_expression (expression) of CIITA in T cells associated with colitis
17) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.93 Pain Relevance 0.13
These data predict that the over-expression of CIITA in T cells should lead to the suppressed Th2 differentiation and an enhanced Th1 differentiation of the CIITA-Tg cells upon activation.
Gene_expression (over) of CIITA in T cells
18) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.74 Pain Relevance 0
Together, these data demonstrate that constitutive expression of CIITA in T cells skews immune response to Th2, resulting in aggravation of Th2-mediated colitis in vivo.



Gene_expression (expression) of CIITA in T cells associated with colitis
19) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2721999 Disease Relevance 0.95 Pain Relevance 0.04
Overexpression of CIITA in T Cells Aggravates Th2-Mediated Colitis in Mice

The MHC class II transactivator (CIITA) is the master transcriptional regulator of genes involved in MHC class II restricted antigen presentation.

Gene_expression (Overexpression) of CIITA associated with colitis
20) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Title Doc Link PMC2721999 Disease Relevance 0.68 Pain Relevance 0.04

General Comments

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