INT278344

From wiki-pain
Revision as of 23:12, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.57
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Hps5) cytoplasm (Hps5)
Anatomy Link Frequency
macrophages 2
Hps5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 40 84.32 Quite High
cytokine 50 75.28 Quite High
chemokine 15 48.00 Quite Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
Inflammatory mediators 10 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 70 84.32 Quite High
Hypertension 5 66.72 Quite High
Apoptosis 10 66.28 Quite High
Fever 30 65.36 Quite High
Rupture 15 55.80 Quite High
Infection 45 53.76 Quite High
Plasmodium Infection 85 45.44 Quite Low
Disease 30 6.40 Low Low
Parasitemia 20 5.00 Very Low Very Low Very Low
Crystal Associated Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Src kinase inhibitor PP2 decreased the Hz-induced Syk phosphorylation in a dose dependent manner (Fig. 5C).
Phosphorylation (phosphorylation) of Hz-induced
1) Confidence 0.39 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.17 Pain Relevance 0
We also showed that the MyD88 signaling pathway is not involved in the Hz-induced Syk phosphorylation.
Phosphorylation (phosphorylation) of Hz-induced
2) Confidence 0.39 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.35 Pain Relevance 0.15
Using BMDM from Lyn-deficient mice, we found that Hz-induced Syk phosphorylation required Lyn, and further confirmed that MSU does not utilize this signaling pathway in either murine or human macrophages (Fig. 5).
Phosphorylation (phosphorylation) of Hz-induced in macrophages
3) Confidence 0.35 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.05 Pain Relevance 0
To evaluate the relative roles of LPS and Hz in the induction of this signaling pathway, we treated BMDM with LPS and we observed that LPS by itself did not induce phospho-Syk, and indeed pre-treatment with LPS reduced Hz-induced Syk phosphorylation (Fig.
Phosphorylation (phosphorylation) of Hz-induced
4) Confidence 0.30 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
Consistent with the involvement of this kinase in a pathway upstream of the inflammasome, NLRP3-, ASC- and NLRC4-deficient macrophages exhibited normal Syk phosphorylation upon Hz stimulation (Fig. 6D).
Phosphorylation (phosphorylation) of Hz in macrophages
5) Confidence 0.30 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox