INT278550

Context Info Confidence 0.48 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 1.31

cytoplasmic membrane-bounded vesicle (SCN8A) transmembrane transport (SCN8A)

SCN8A (Homo sapiens)

Pain Link Frequency Relevance Heat Nav1.1 8 100.00 nav1.3 7 100.00 Nav1.2 5 100.00 tetrodotoxin 9 99.44 Nav1.6 7 99.36 Nav1.7 7 98.00 nav1.8 9 84.16 Nav1.9 4 81.36 Action potential 1 74.56 sodium channel 7 69.52

Disease Link Frequency Relevance Heat Sperm Disorder 15 29.84 Nociception 1 5.00 Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

subunits are inhibited by TTX in the nanomolar range and include SCN1A (also known as Nav1.1), SCN2A (also known as Nav1.2), SCN3A (also known as Nav1.3), SCN4A (also known as Nav1.4), SCN8A (also known as Nav1.6), and SCN9A (also known as Nav1.7).

Positive_regulation (include) of SCN8A associated with nav1.3, tetrodotoxin, nav1.1, nav1.2, nav1.7 and nav1.6

1) Confidence 0.48 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 1.31

General Comments

This test has worked.