INT278694

Context Info Confidence 0.03 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.79 Pain Relevance 0.56

signal transduction (TNF, MAPK14) nucleoplasm (MAPK14) intracellular (TNF) extracellular matrix organization (TNF) response to stress (MAPK14) cytoplasm (MAPK14)

TNF (Homo sapiens) MAPK14 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 13 97.76 cytokine 8 97.24 methotrexate 14 90.92 rheumatoid arthritis 77 72.92 Arthritis 2 64.60 Leflunomide 15 49.04 Potency 1 43.52 metalloproteinase 1 23.32 Pain 2 12.00 corticosteroid 3 9.92

Disease Link Frequency Relevance Heat Disease 29 98.44 INFLAMMATION 12 97.76 Rheumatoid Arthritis 122 72.92 Experimental Arthritis 1 64.60 Pressure And Volume Under Development 2 12.52 Pain 2 12.00 Frailty 34 5.00 Autoimmune Disease 7 5.00 Disease Progression 6 5.00 Arthritis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TNF activates multiple kinases (p38, ERK, JNK) and will induce the expression of other pro-inflammatory cytokines that, in turn, invoke pro-inflammatory signaling events associated with kinase activation.

TNF Positive_regulation (activates) of p38 associated with inflammation and cytokine

1) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.79 Pain Relevance 0.56

General Comments

This test has worked.