INT278718

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.55
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT5B) nucleoplasm (STAT5B) nucleus (STAT5B)
cytoplasm (STAT5B) signal transducer activity (STAT5B)
STAT5B (Homo sapiens)
Pain Link Frequency Relevance Heat
Leflunomide 15 77.32 Quite High
corticosteroid 3 67.32 Quite High
agonist 8 64.64 Quite High
methotrexate 14 63.52 Quite High
Arthritis 2 50.00 Quite Low
cINOD 2 47.92 Quite Low
rheumatoid arthritis 77 5.00 Very Low Very Low Very Low
Osteoarthritis 32 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Growth Problems 200 97.56 Very High Very High Very High
Immunodeficiency 2 87.48 High High
Congenital Anomalies 2 53.56 Quite High
Syndrome 4 50.24 Quite High
Rheumatoid Arthritis 122 50.00 Quite Low
INFLAMMATION 12 47.40 Quite Low
Turner's Syndrome 4 46.20 Quite Low
Disease 31 30.52 Quite Low
Frailty 34 5.00 Very Low Very Low Very Low
Growth Hormone Deficiency 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic explanations for ISS have occurred in approximately 5% of the patients evaluated, including genetic mutations of the GH-IGF-1 axis, including STAT5b mutations, SHOX gene mutations, and ALS mutations.
Gene_expression (mutations) of STAT5b associated with growth problems
1) Confidence 0.43 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2898102 Disease Relevance 0.56 Pain Relevance 0.03
Also, it has been pointed out that the phenotype of STAT5b-deficiency is that of severe GH-resistance, and it is not likely to be mistaken for ISS.64 Perhaps the reason that ALS-deficiency has not been identified in a population of ISS patients is because the growth failure associated with it is too subtle for the affected child to be labeled as having ISS.
Gene_expression (phenotype) of STAT5b-deficiency associated with growth problems
2) Confidence 0.43 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2898102 Disease Relevance 0.99 Pain Relevance 0
, and p-STAT5 were also observed in their CD8+ cells and reductions in p-p38 were observed in their CD20+ cells.
Gene_expression (observed) of p-STAT5
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0 Pain Relevance 0.31

General Comments

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