INT27912

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Context Info
Confidence 0.35
First Reported 1989
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.83
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CD86 1
immune system 1
hindlimb muscle 1
hindlimb 1
H2-K1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1 100.00 Very High Very High Very High
tetrodotoxin 3 98.60 Very High Very High Very High
antagonist 3 90.44 High High
Inflammation 32 79.60 Quite High
Pain 4 79.24 Quite High
chemokine 8 78.16 Quite High
cytokine 18 74.24 Quite High
Neuropeptide 4 50.00 Quite Low
tolerance 3 49.88 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 46 99.16 Very High Very High Very High
Ulcers 3 98.40 Very High Very High Very High
Duodenal Ulcer 1 97.72 Very High Very High Very High
Cancer 153 97.36 Very High Very High Very High
Infection 69 95.36 Very High Very High Very High
Viral Meningitis 3 94.48 High High
Suicidal Behaviour 16 91.40 High High
Disease 19 88.88 High High
Immunotherapy Of Cancer 6 88.28 High High
Death 9 84.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, 1.8 mM ouabain inhibited 40 +/- 8% of the total JinK in 38 +/- 2 min, but did not significantly affect JoutK.
Neg (not) Regulation (affect) of JoutK
1) Confidence 0.35 Published 2001 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 11760095 Disease Relevance 0 Pain Relevance 0
In both rat hindlimb and mouse FDB, tetracaine had no effect on JoutK.
Neg (no) Regulation (effect) of JoutK in hindlimb
2) Confidence 0.30 Published 2001 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 11760095 Disease Relevance 0 Pain Relevance 0.10
Perfusion of hindlimb muscle with 0.1 mM tetrodotoxin (TTX, a Na+ channel blocker) decreased JinK by 15 +/- 1%, but had no effect on JoutK; subsequent addition of ouabain (5 mM) decreased JinK a further 32 +/- 2%.
Neg (no) Regulation (effect) of JoutK in hindlimb muscle associated with tetrodotoxin
3) Confidence 0.13 Published 2001 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 11760095 Disease Relevance 0 Pain Relevance 0.10
This expression pattern suggested a crucial role of MC-1R signaling in the regulation of MHC class I-restricted immunity.
Regulation (regulation) of MHC class I
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.05 Pain Relevance 0
The list of validated genes includes those associated with retinoic acid receptor (RAR) signaling - retinol dehydrogenase 9 (Rdh9); immune system regulation - histocompatibility 2 K1, K region (H2-K1), interferon regulatory factor 6 (Irf6), and endoplasmic reticulum aminopeptidase 1 (Erap1); lipid and insulin metabolism - stearoyl coenzyme A desaturase (Scd1), oxysterol binding protein-like 1A (Osbpl1a), and insulin receptor substrate 1 (Irs1); and two genes that have not yet been characterized (Ai117581, Riken C030034E14).
Regulation (em regulat) of H2-K1 in immune system
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975639 Disease Relevance 0 Pain Relevance 0
The NSPCs residing in the subventricular zone of the infected brains showed prominent expression of MHC-I and costimulatory molecules CD40, CD80, and CD86.
Regulation (molecules) of MHC-I in CD86
6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2780913 Disease Relevance 0.65 Pain Relevance 0.15
Efficacy of the H+/K+-adenosine triphosphatase inhibitor omeprazole in peptic ulcer.
Regulation (Efficacy) of H+/K+-adenosine associated with adenocard and ulcers
7) Confidence 0.01 Published 1989 Journal Digestion Section Title Doc Link 2691308 Disease Relevance 0.59 Pain Relevance 0.30
However, only a few workers have reported precise regulation of the HSVtk gene.
Regulation (regulation) of HSVtk
8) Confidence 0.00 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1463003 Disease Relevance 1.04 Pain Relevance 0
Recombinant AAV-mediated HSVtk gene transfer with direct intratumoral injections and Tet-On regulation for implanted human breast cancer

Background

Regulation (regulation) of HSVtk associated with breast cancer
9) Confidence 0.00 Published 2006 Journal BMC Cancer Section Title Doc Link PMC1463003 Disease Relevance 0.49 Pain Relevance 0

General Comments

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