INT279275

Context Info Confidence 0.05 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.02 Pain Relevance 0.06

DNA binding (TXK) embryo development (PDGFA) cytoplasm (TXK) cell-cell signaling (PDGFA) extracellular space (PDGFA) extracellular region (PDGFA)

Anatomy Link Frequency Platelet 2 PDGFA (Homo sapiens) TXK (Homo sapiens)

Pain Link Frequency Relevance Heat Potency 2 59.20 cytokine 4 5.00 tolerance 2 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Pancreatic Cancer 138 98.36 Fatigue 4 91.16 Solid Tumor 6 67.96 Cancer 68 63.76 Glioblastoma 2 36.16 Sarcoma 4 35.04 Colon Cancer 2 33.68 Disease 18 31.28 Metastasis 10 5.00 Apoptosis 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Platelet-derived growth factor ligands, PDGF-A and PDGF-B, exert their effects on target cells by activating the two structurally related protein tyrosine kinase receptors, PDGFR-?

PDGF Positive_regulation (activating) of tyrosine kinase in Platelet

1) Confidence 0.05 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.51 Pain Relevance 0.03

Platelet-derived growth factor ligands, PDGF-A and PDGF-B, exert their effects on target cells by activating the two structurally related protein tyrosine kinase receptors, PDGFR-?

PDGF Positive_regulation (activating) of tyrosine kinase in Platelet

2) Confidence 0.05 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.51 Pain Relevance 0.03

General Comments

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