INT279505

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.21 Pain Relevance 0

extracellular space (C4b, Abpz) extracellular region (C4b, Abpz) molecular_function (Abpz) cellular_component (Abpz) biological_process (Abpz)

C4b (Mus musculus) Abpz (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory response 2 14.96 Inflammation 7 14.40 ischemia 12 5.00 cva 8 5.00 tissue acidosis 1 5.00 rheumatoid arthritis 1 5.00 abdominal pain 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Myocardial Infarction 49 53.88 Coronary Artery Disease 16 52.96 Heart Disease 2 51.56 Glomerulonephritis 23 50.80 Paroxysmal Nocturnal Hemoglobinuria 27 50.00 Disease 14 48.24 INFLAMMATION 9 14.60 Death 14 5.00 Cv Unclassified Under Development 11 5.00 Sepsis 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activated C1s cleaves C4 and C2 to form C4b and C2b, respectively, which then combine to form the C3 convertase of the classical complement pathway (Figure 1).

C4 Binding (form) of C2b

1) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.21 Pain Relevance 0

General Comments

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