INT27956

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.37
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PENK) extracellular region (PENK)
Anatomy Link Frequency
nerve 2
striatum 2
PVN 2
PENK (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 4 99.80 Very High Very High Very High
dexamethasone 4 98.16 Very High Very High Very High
antagonist 3 96.42 Very High Very High Very High
Dopamine 2 94.08 High High
Neuropeptide 5 91.12 High High
Neurotransmitter 1 90.00 High High
Opioid 1 87.52 High High
Enkephalin 12 79.88 Quite High
opiate 2 77.12 Quite High
Glutamate receptor 3 75.12 Quite High
Disease Link Frequency Relevance Heat
Stress 12 100.00 Very High Very High Very High
Parkinson's Disease 10 87.44 High High
Disease 1 75.00 Quite High
Mental Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Triple (3 h apart), bilateral, intrastriatal administration of selective antagonists of mGluR1: (S)-(+)-alpha-amino-4-carboxy-2-methylbenzeneacetic acid (3 x 5 microg/0.5 microl) or 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate (3 x 2.5 microg/0.5 microl), reversed the haloperidol-induced increases in proenkephalin mRNA levels in the rostral and central regions of the striatum.
Negative_regulation (reversed) of Positive_regulation (increases) of proenkephalin in striatum associated with antagonist
1) Confidence 0.43 Published 2003 Journal Neuroscience Section Abstract Doc Link 14622918 Disease Relevance 0.23 Pain Relevance 0.38
However, unilateral implants of dexamethasone significantly decreased basal CRF mRNA compared to the contralateral, unimplanted side and prevented the increase in CRF and proenkephalin A mRNA 4 hours after ip hypertonic saline stress.
Negative_regulation (prevented) of Positive_regulation (increase) of proenkephalin A associated with stress and dexamethasone
2) Confidence 0.42 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2789345 Disease Relevance 0.43 Pain Relevance 0.17
The activation of receptors coupled to adenylate cyclase elicited the increase of proenkephalin and nerve growth factor gene expression.
Negative_regulation (elicited) of Positive_regulation (increase) of proenkephalin in nerve associated with nerve growth factor
3) Confidence 0.41 Published 1989 Journal Pharmacol. Res. Section Abstract Doc Link 2698474 Disease Relevance 0 Pain Relevance 0.30
Unilateral implants of cholesterol directly over the PVN had no effect on either basal or stress-induced increase of CRF and proenkephalin A message.
Negative_regulation (stress-induced) of Positive_regulation (increase) of proenkephalin A in PVN associated with stress
4) Confidence 0.41 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2789345 Disease Relevance 0.42 Pain Relevance 0.15
Inhibition of L-type Ca2+ channels blocks forskolin-mediated induction of proenkephalin.
Negative_regulation (blocks) of Positive_regulation (induction) of proenkephalin
5) Confidence 0.41 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12877986 Disease Relevance 0 Pain Relevance 0.08
L-DOPA therapy given on an intermittent schedule reverses the decrease in preprotachykinin messenger RNA, but fails to reverse the increase in preproenkephalin messenger RNA in the same animal.
Negative_regulation (reverse) of Positive_regulation (increase) of preproenkephalin
6) Confidence 0.04 Published 1995 Journal Neuroscience Section Abstract Doc Link 8544992 Disease Relevance 0.29 Pain Relevance 0.17

General Comments

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