INT27964

Context Info Confidence 0.58 First Reported 1973 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 12 Total Number 12 Disease Relevance 5.48 Pain Relevance 3.74

oxidoreductase activity (CBR1) cytoplasm (CBR1)

Anatomy Link Frequency muscle 1 platelets 1 skin 1 kidney 1 CBR1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 16 100.00 alcohol 1 99.92 diclofenac 3 99.62 Dismenorea 6 99.60 Pain 15 99.40 Inflammation 12 98.72 cytokine 1 92.68 endometriosis 4 92.24 aspirin 3 86.44 Serotonin 1 82.16

Disease Link Frequency Relevance Heat INFLAMMATION 23 100.00 Cholecystitis 11 99.92 Dysmenorrhea 5 99.60 Pain 14 99.40 Shock 2 99.16 Cancer 3 97.88 Periodontal Disease 2 96.60 Gallbladder Disease 2 96.14 Coagulation Disorder 1 95.52 Sepsis 3 94.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The qualitative effects of zomepirac on platelets are assumed to be the consequence of reversible inhibition of prostaglandin synthetase in these cells.

Negative_regulation (inhibition) of prostaglandin synthetase in platelets

1) Confidence 0.58 Published 1980 Journal J Clin Pharmacol Section Abstract Doc Link 7400378 Disease Relevance 0.26 Pain Relevance 0.19

However, the long-term use of anti-inflammatory drugs in the treatment in periodontal disease requires confirmation of experimental results in long-term prospective and independent trials in humans, and elucidation and control of possible side effects due to the inhibition of prostaglandin-sintetase.

Negative_regulation (inhibition) of prostaglandin-sintetase associated with inflammation, cinod and periodontal disease

2) Confidence 0.58 Published 1989 Journal Av Odontoestomatol Section Abstract Doc Link 2700615 Disease Relevance 0.51 Pain Relevance 0.25

Indomethacin is an effective inhibitor of prostaglandin synthetase and has recently been demonstrated to inhibit inflammatory fluid secretion into the gallbladder in experimental cholecystitis.

Negative_regulation (inhibitor) of prostaglandin synthetase associated with inflammation and cholecystitis

3) Confidence 0.43 Published 1981 Journal Surgery Section Abstract Doc Link 7268625 Disease Relevance 0.71 Pain Relevance 0.30

The inhibitory effects of some anti-inflammatory drugs on skin microsomal prostaglandin synthetase were also demonstrated in these studies.

Negative_regulation (effects) of prostaglandin synthetase in skin associated with inflammation and cinod

4) Confidence 0.37 Published 1973 Journal J. Lipid Res. Section Abstract Doc Link 4197607 Disease Relevance 0.17 Pain Relevance 0.26

Stereoselective inhibition of carbonyl reductase from rabbit kidney by enantiomers of carprofen.

Negative_regulation (inhibition) of carbonyl reductase in kidney

5) Confidence 0.33 Published 1994 Journal Biochem. Mol. Biol. Int. Section Title Doc Link 8032320 Disease Relevance 0.10 Pain Relevance 0.28

Prostaglandin synthetase inhibitors, non-steroidal anti-inflammatory drugs, have been utilized for the past two decades in many animal studies, especially in endotoxin or septic shock, to determine what effects they might have.

Negative_regulation (inhibitors) of Prostaglandin synthetase associated with inflammation, cinod and sepsis

6) Confidence 0.28 Published 1983 Journal Adv Shock Res Section Abstract Doc Link 6410700 Disease Relevance 0.45 Pain Relevance 0.10

Formation of M4 and M5 was catalyzed by NADPH-dependent hepatic cytosolic enzymes, which were identified using selective chemical inhibitors (10 and 100 microM) for aldo-keto reductase (AKR) isoforms, short-chain dehydrogenase/reductase including carbonyl reductase, alcohol dehydrogenase, and quinone oxidoreductase.

Negative_regulation (inhibitors) of carbonyl reductase associated with alcohol

7) Confidence 0.12 Published 2010 Journal Drug Metab. Dispos. Section Abstract Doc Link 20173089 Disease Relevance 0.15 Pain Relevance 0.26

Since both indomethacin and diclofenac sodium are potent inhibitors of prostaglandin synthetase, these findings are consistent with the hypothesis tht prostaglandins are involved in the feed-back regulation of lipolysis, and mediate the inhibitory effect of lipolysis on lipoprotein lipase activity.

Negative_regulation (inhibitors) of prostaglandin synthetase associated with diclofenac

8) Confidence 0.09 Published 1981 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6796423 Disease Relevance 0.07 Pain Relevance 0.22

It is estimated that 10-30% of patients with painful periods fail to respond to prostaglandin (PG) synthetase inhibitors.

Negative_regulation (inhibitors) of prostaglandin associated with dismenorea

9) Confidence 0.07 Published 2000 Journal Hum. Reprod. Update Section Abstract Doc Link 10782578 Disease Relevance 0.91 Pain Relevance 0.70

In a randomized double-blind trial, the effect of ibuprofen on the pain produced by gallbladder disease and on gallbladder mucosa and muscle wall tissue PGE and PGF production was evaluated to determine if the pain of cholecystitis and prostaglandin formation were altered by administration of a prostaglandin synthetase inhibitor.

Negative_regulation (inhibitor) of prostaglandin synthetase in muscle associated with pain, gallbladder disease and cholecystitis

10) Confidence 0.05 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 3896701 Disease Relevance 0.51 Pain Relevance 0.25

Prostaglandin synthetase inhibition decreases the pain associated with cholecystitis; however, the absence of correlation with decreased PGE formation suggests that other prostanoids may play an important role in producing the symptoms of cholecystitis.

Negative_regulation (inhibition) of Prostaglandin synthetase associated with pain and cholecystitis

11) Confidence 0.05 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 3896701 Disease Relevance 1.07 Pain Relevance 0.49

Non-steroidal anti-inflammatory drugs (NSAIDs) are known to inhibit prostaglandin synthetic enzyme, cyclooxygenases (COXs), as well as to exhibit anti-tumor activity although at much higher concentrations. 15-Hydroxyprostaglandin dehyrogenase (15-PGDH), a key prostaglandin catabolic enzyme, was recently shown to be a tumor suppressor.

Negative_regulation (inhibit) of prostaglandin synthetic enzyme associated with inflammation, cancer and cinod

12) Confidence 0.04 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.57 Pain Relevance 0.43

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