INT279707

Context Info Confidence 0.00 First Reported 2009 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.09

pigmentation (TYRP1) plasma membrane (AGTR1) signal transducer activity (AGTR1)

Anatomy Link Frequency smooth muscle cells 2 AGTR1 (Homo sapiens) TYRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat TRP channel 5 100.00 Mechanosensation 2 82.76 nociceptor 3 5.00 withdrawal 2 5.00 Pain 2 5.00 imagery 2 5.00 qutenza 1 5.00 Serotonin 1 5.00

Disease Link Frequency Relevance Heat Helminth Infection 14 5.00 Sprains And Strains 9 5.00 Pain 2 5.00 Targeted Disruption 2 5.00 Heart Rate Under Development 2 5.00 Arterial-venous Cerebral Malformations 1 5.00 Nociception 1 5.00 Loss Of Sense Of Smell 1 5.00 Injury 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In these vascular smooth muscle cells ligand independent activation of the Angiotensisn II AT1 receptor by membrane stretch regulates a TRP channel, TRPC6, through a mechanism that requires both G?

Neg (30268) Positive_regulation (activation) of Angiotensisn II AT1 receptor in smooth muscle cells Regulation (regulates) of TRP associated with trp channel

1) Confidence 0.00 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0 Pain Relevance 0.09

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