INT279798

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.00
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (APAF1, CASP3) cytosol (APAF1, CASP3) nucleolus (APAF1, CASP3)
nucleus (APAF1, CASP3) nucleoplasm (CASP3) mitochondrion (CASP3)
APAF1 (Homo sapiens)
CASP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 1 41.36 Quite Low
complementary and alternative medicine 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 45 98.00 Very High Very High Very High
Death 12 84.16 Quite High
Breast Cancer 48 50.00 Quite Low
Malignant Neoplastic Disease 1 45.72 Quite Low
Shock 1 40.00 Quite Low
Cancer 13 29.52 Quite Low
Necrosis 1 29.04 Quite Low
Stress 3 5.52 Low Low
Disease 5 5.16 Low Low
Fatigue 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once in the cytosol, cytochrome c activates Apaf-1, which then activates procaspase-9, which, in turn, activates caspase-3, triggering apoptosis.
Apaf-1 Positive_regulation (activates) of procaspase-9 associated with apoptosis
1) Confidence 0.01 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 1.00 Pain Relevance 0

General Comments

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