INT279819

Context Info Confidence 0.12 First Reported 2009 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.67 Pain Relevance 0.03

nucleolus (Acin1) nucleus (Acin1) cytoplasm (Acin1)

Anatomy Link Frequency ACN 2 Acin1 (Mus musculus)

Pain Link Frequency Relevance Heat Electroencephalography 1 66.00 Nav1.7 10 5.00 Pain 9 5.00 Paroxysmal extreme pain disorder 7 5.00 primary erythermalgia 5 5.00 sodium channel 4 5.00 anticonvulsant 3 5.00 Migraine 2 5.00 Central nervous system 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Convulsion 72 93.00 Febrile Convulsions 60 76.44 Syncope 2 55.84 Absence Epilepsy 1 51.76 Epilepsy 22 50.00 Sclerosis 1 37.60 Partial Seizures 7 35.44 Death 1 35.36 Syndrome 46 5.00 Disease 15 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Briefly, the following changes were introduced into the wild-type Scn9a (Figure 2A): the p.N641Y mutation into exon 11, the ACN positive selection vector into intron 10, and the negative TK selection vector into intron 12 (Figure 2B).

Positive_regulation (negative) of Neg (negative) Gene_expression (introduced) of ACN in ACN

1) Confidence 0.12 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 0.67 Pain Relevance 0.03

General Comments

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