INT280166

Context Info Confidence 0.19 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.78 Pain Relevance 0

nucleus (MAPK8, Twist1) cell differentiation (Twist1) nucleoplasm (MAPK8) mitochondrion (MAPK8) DNA binding (Twist1) response to stress (MAPK8)

MAPK8 (Homo sapiens) Twist1 (Mus musculus)

Pain Link Frequency Relevance Heat palliative 1 5.00 psoriasis 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat Cancer 37 100.00 Apoptosis 29 93.16 Shock 4 80.56 Stress 2 67.00 Death 9 60.96 Hepatocellular Cancer 20 50.00 Injury 1 45.88 Wrinkles 1 34.64 Liver Cancer 5 5.00 Skin Cancer 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PDT is recently reported to reduce the expression of P-glycoprotein in cancer cells, however, the linkage of JNK pathway and PDT-induced down-regulation of P-glycoprotein is not yet investigated [34].

JNK Binding (linkage) of PDT associated with cancer

1) Confidence 0.19 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.78 Pain Relevance 0

General Comments

This test has worked.