INT280477

Context Info Confidence 0.03 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.08 Pain Relevance 0

cytoplasmic membrane-bounded vesicle (Bdnf, Sort1) cell differentiation (Sort1) endosome (Sort1) transport (Sort1) Golgi apparatus (Sort1) endoplasmic reticulum (Sort1)

Bdnf (Mus musculus) Sort1 (Mus musculus)

Pain Link Frequency Relevance Heat depression 73 50.00 Nerve growth factor 4 45.08 antidepressant 62 5.00 Hippocampus 43 5.00 fluoxetine 18 5.00 Desipramine 10 5.00 Central nervous system 5 5.00 Eae 4 5.00 midbrain 3 5.00 amygdala 3 5.00

Disease Link Frequency Relevance Heat Mental Disorders 6 82.20 Depression 95 50.00 Congenital Anomalies 9 25.48 Suicidal Behaviour 123 5.00 Stress 25 5.00 Urological Neuroanatomy 17 5.00 Apoptosis 6 5.00 Targeted Disruption 6 5.00 Death 4 5.00 Cognitive Disorder 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has been suggested that pro-BDNF binds to sortilin in the Golgi, which facilitates the correct folding of the mature domain.

BDNF Binding (binds) of sortilin

1) Confidence 0.03 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.08 Pain Relevance 0

General Comments

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