INT280614

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.40
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Il6) cytoplasm (Irs1) signal transducer activity (Irs1)
cytosol (Irs1) extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
muscle 2
Il6 (Rattus norvegicus)
Irs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 72 98.12 Very High Very High Very High
Inflammation 9 84.20 Quite High
cytokine 9 82.96 Quite High
dexamethasone 15 74.32 Quite High
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 60 90.56 High High
INFLAMMATION 9 84.20 Quite High
Obesity 3 64.40 Quite High
Diabetes Mellitus 15 56.20 Quite High
Exsanguination 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Frailty 6 5.00 Very Low Very Low Very Low
Metabolic Syndrome 6 5.00 Very Low Very Low Very Low
Repression 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, interleukin 6 (IL-6) exerts long-term inhibitory effects on the transcription of IRS-1 while IL-6 receptor expression is enhanced by CS treatment (Rotter et al. 2003).
IL-6 Regulation (effects) of Transcription (transcription) of IRS-1 associated with corticosteroid
1) Confidence 0.26 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.13
Thus it is reasonable to assume that increased expression of IL-6 receptor potentially enhances muscle sensitivity to IL-6 and augments the inhibitory effect of IL-6 on IRS-1 transcription.
IL-6 Regulation (effect) of Transcription (transcription) of IRS-1 in muscle
2) Confidence 0.26 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.40 Pain Relevance 0.19
Additionally, interleukin 6 (IL-6) exerts long-term inhibitory effects on the transcription of IRS-1 while IL-6 receptor expression is enhanced by CS treatment (Rotter et al. 2003).
interleukin 6 Regulation (effects) of Transcription (transcription) of IRS-1 associated with corticosteroid
3) Confidence 0.26 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.13

General Comments

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