INT280925

Context Info Confidence 0.53 First Reported 2009 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 3.91 Pain Relevance 0.03

extracellular space (Prom1) plasma membrane (Prom1) cilium (Prom1)

Anatomy Link Frequency blood 1 brain 1 NSCs 1 Prom1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 29 68.32 imagery 32 50.00 Central nervous system 16 5.00 neurotrophin 3 16 5.00 anesthesia 3 5.00 Inflammatory response 3 5.00 long-term potentiation 2 5.00 cerebral cortex 2 5.00 cytokine 2 5.00 fibrosis 2 5.00

Disease Link Frequency Relevance Heat Infection 96 99.98 Cytomegalovirus Infection 126 99.66 Viral Infection 26 99.42 Neurodegenerative Disease 12 91.76 Cancer 84 89.92 Injury 119 85.80 INFLAMMATION 32 68.32 Sensorineural Hearing Loss 2 65.28 Cerebral Palsy 2 64.00 Intellectual Impairment 6 63.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A decrease of the CD133 expression levels in vivo might provide an explanation for the apparently smaller difference in CD133 expression in vivo compared to in vitro.

Negative_regulation (decrease) of CD133

1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004948 Disease Relevance 0.29 Pain Relevance 0

MCMV brain infection reduces CD133(+) cell number and alters nestin expression

Negative_regulation (reduces) of CD133 in brain associated with cytomegalovirus infection and infection

2) Confidence 0.31 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 1.05 Pain Relevance 0

In addition, viral infection was demonstrated to cause a loss of NSCs expressing CD133 and nestin.

Negative_regulation (loss) of CD133 in NSCs associated with viral infection

3) Confidence 0.23 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020957 Disease Relevance 1.79 Pain Relevance 0

Flow cytometry was performed to analyze cleared peripheral blood samples using GFP, Cd34, and Cd133 as markers of EPCs at the following time points: day 0, day 4, day 7, and day 14.

Negative_regulation (using) of Cd133 in blood

4) Confidence 0.20 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.78 Pain Relevance 0.03

General Comments

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