INT281073

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Context Info
Confidence 0.56
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 0.72
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Anatomy Link Frequency
dorsal 4
spinal cord 2
lamina 2
hippocampus 2
anterior 1
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 82 100.00 Very High Very High Very High
Dorsal horn 12 100.00 Very High Very High Very High
Hippocampus 209 99.84 Very High Very High Very High
Pyramidal cell 56 99.40 Very High Very High Very High
Spinal cord 20 98.28 Very High Very High Very High
long-term potentiation 236 94.68 High High
spinal dorsal horn 14 93.72 High High
Glutamate receptor 27 92.56 High High
amygdala 8 89.12 High High
projection neuron 2 79.60 Quite High
Disease Link Frequency Relevance Heat
Nociception 59 99.88 Very High Very High Very High
Death 12 96.00 Very High Very High Very High
Targeted Disruption 44 88.00 High High
Depression 5 78.16 Quite High
Hypersensitivity 13 60.56 Quite High
Anxiety Disorder 112 56.64 Quite High
Nervous System Injury 4 43.00 Quite Low
Pain 52 24.88 Low Low
Shock 108 5.00 Very Low Very Low Very Low
Convulsion 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, we observed a significant loss of GluR2 expression in dorsal CA1 pyramidal neurons in the GluR2-cKO mice at 6 weeks and 8 weeks of age compared to control mice of the same age (57.7±3.0% vs 91.8±1.4% at 6 weeks and 52.8±2.2% vs 95.2±0.4% at 8 weeks; p values<.05).
Negative_regulation (loss) of Gene_expression (expression) of GluR2 in dorsal associated with pyramidal cell
1) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.26
These combined results demonstrate that while GluR2 expression is significantly reduced from the expected regions of the dorsal hippocampus of mutant mice this loss does not lead to cell death in mice at eight weeks of age.
Negative_regulation (reduced) of Gene_expression (expression) of GluR2 in dorsal associated with hippocampus and death
2) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.26 Pain Relevance 0.24
Consequently, a potential mechanism for NMDAR-independent learning and plasticity in the hippocampus is the expression and activation of GluR2-lacking (Ca2+-permeable) AMPARs.
Negative_regulation (lacking) of Gene_expression (expression) of GluR2 in hippocampus associated with hippocampus
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.06 Pain Relevance 0.34
The expression of GluR2 was observed throughout the dorsal horn and was abundant in inner lamina II and sparse in outer lamina II.
Negative_regulation (abundant) of Gene_expression (expression) of GluR2 in lamina associated with dorsal horn
4) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0 Pain Relevance 0.47
AC: adenylyl cyclase; ACC: anterior cingulate cortex; ACSF: artificial cerebrospinal fluid; AMPA: ?
Negative_regulation (cerebrospinal fluid) of in cerebrospinal fluid Gene_expression (adenylyl cyclase) of AMPA in anterior associated with anterior cingulate cortex
5) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.14 Pain Relevance 0.30
This suggests that GluR2 deletion in CA1 selectively impairs NMDAR-dependent learning.
Negative_regulation (impairs) of Gene_expression (deletion) of GluR2
6) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.18
Structure of AMPA receptor channels, their expression and localization in the spinal cord
Negative_regulation (Structure) of Gene_expression (channels) of AMPA receptor in spinal cord associated with spinal cord
7) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.26 Pain Relevance 0.38

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