INT281192

Context Info Confidence 0.23 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.12

signal transduction (Casr) endoplasmic reticulum (Insig1) plasma membrane (Casr) lipid metabolic process (Insig1) signal transducer activity (Casr)

Anatomy Link Frequency CAR 1 Casr (Mus musculus) Insig1 (Mus musculus)

Pain Link Frequency Relevance Heat Bile 14 86.16 Crohn's disease 1 15.16 Inflammation 1 12.64 anesthesia 8 5.00

Disease Link Frequency Relevance Heat Disease 1 15.16 Diabetes Mellitus 1 14.36 Obesity 3 13.68 INFLAMMATION 1 12.64 Body Weight 10 5.00 Aging 5 5.00 Dislocations 1 5.00 Anxiety Disorder 1 5.00 Attention Deficit Hyperactivity Disorder 1 5.00 Cognitive Disorder 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This report elegantly provided an explanation as to how an activation of xenobiotic metabolism regulators like CAR and PXR induce Insig-1 by CAR and PXR which may explain the negative effects of some drugs on hepatic lipid levels [14].

CAR Positive_regulation (induce) of Insig-1 in CAR

1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.12

General Comments

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