INT281253

Context Info Confidence 0.09 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.49 Pain Relevance 0

endosome (LAMTOR1) Golgi apparatus (LAMTOR1) plasma membrane (LAMTOR1) lysosome (LAMTOR1)

LAMTOR1 (Homo sapiens)

Pain Link Frequency Relevance Heat positron emission tomography 4 5.00 imagery 1 5.00 backache 1 5.00

Disease Link Frequency Relevance Heat Retinoblastoma 1 98.86 Congenital Anomalies 6 98.42 Testicular Cancer 147 96.86 Carcinoma In Situ 8 88.72 Seminoma 32 87.76 Disease 28 76.28 Cancer 60 73.16 Isochromosomes 1 58.52 Triploidy 1 48.32 Aneuploidy 1 46.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In particular, TGCT has been shown to be associated with a characteristic series of abnormalities in the retinoblastoma pathway including upregulation of cyclin D2 and p27 and downregulation of RB1 and the cyclin-dependent kinase inhibitors of p16, p18, p19 and p21 [13].

Negative_regulation (downregulation) of Negative_regulation (inhibitors) of p18 associated with congenital anomalies, testicular cancer and retinoblastoma

1) Confidence 0.09 Published 2008 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2735737 Disease Relevance 1.49 Pain Relevance 0

General Comments

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