INT28130

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Context Info
Confidence 0.61
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 7.08
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA1) small molecule metabolic process (ABCA1) Golgi apparatus (ABCA1)
ATPase activity (ABCA1) plasma membrane (ABCA1) intracellular (ABCA1)
Anatomy Link Frequency
macrophages 2
plasma 2
adipocyte 2
granulocytes 1
epithelial cells 1
ABCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 34 99.48 Very High Very High Very High
agonist 16 98.56 Very High Very High Very High
Inflammation 91 98.12 Very High Very High Very High
allodynia 3 97.56 Very High Very High Very High
Calcium channel 3 95.68 Very High Very High Very High
Peripheral nervous system 6 91.80 High High
anesthesia 5 91.16 High High
Clonidine 7 88.56 High High
lidocaine 2 88.00 High High
Angina 1 86.96 High High
Disease Link Frequency Relevance Heat
Apoptosis 67 100.00 Very High Very High Very High
Stress 17 99.84 Very High Very High Very High
Atherosclerosis 32 98.82 Very High Very High Very High
Disease 34 98.52 Very High Very High Very High
INFLAMMATION 98 98.12 Very High Very High Very High
Neuropathic Pain 4 97.56 Very High Very High Very High
Insulin Resistance 1 96.52 Very High Very High Very High
Neuroblastoma 2 93.92 High High
Disorder Of Lipid Metabolism 194 93.28 High High
Inflammatory Bowel Disease 4 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that the effect of the apoA-I is not directly linked to the activation of ABCA1, or at least, that in adipocyte, the activation of ABCA1 occurs through an undescribed signaling pathway.
Positive_regulation (activation) of ABCA1 in adipocyte
1) Confidence 0.61 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.33 Pain Relevance 0
This suggests that the effect of the apoA-I is not directly linked to the activation of ABCA1, or at least, that in adipocyte, the activation of ABCA1 occurs through an undescribed signaling pathway.
Positive_regulation (activation) of ABCA1 in adipocyte
2) Confidence 0.61 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.32 Pain Relevance 0
Our data demonstrate that pharmacological inhibition of COX reduces expression of the cholesterol-metabolizing enzyme cholesterol 27-hydroxylase and the cholesterol transport protein ABCA1.
Positive_regulation (metabolizing) of ABCA1
3) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.37 Pain Relevance 0.17
PPAR agonists have been postulated to increase macrophage cholesterol efflux through increased levels of ABCA1 and ABCG1.
Positive_regulation (increased) of ABCA1 in macrophage associated with agonist
4) Confidence 0.39 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 0.92 Pain Relevance 0.09
Previous reports suggested an important role of cAMP in the modulation of atherosclerotic plaque progression by removal of excess free cholesterol from macrophages by inducing the ABCA1 secretory pathway and reducing circulating levels of cholesterol.
Positive_regulation (inducing) of ABCA1 in macrophages associated with atherosclerosis
5) Confidence 0.16 Published 2010 Journal Curr Vasc Pharmacol Section Abstract Doc Link 19485905 Disease Relevance 1.04 Pain Relevance 0.21
As in the case of the aforementioned membrane-bound glycoprotein, NEP activity decreased significantly in CCRCC (fourfold), ChRCC (fivefold) and RO (sevenfold) when compared with the normal tissue samples.
Positive_regulation (aforementioned) of membrane-bound
6) Confidence 0.09 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.63 Pain Relevance 0
The resulting supernatants were used to measure soluble DPP IV activity, which is a truncated form of membrane-bound DPP IV/CD26 lacking some residues in the N-terminal aminoacids [16].
Positive_regulation (form) of membrane-bound
7) Confidence 0.09 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.26 Pain Relevance 0
Incubation of granulocytes with chlorpromazine results in decreased activation of the plasma membrane superoxide generating NADPH oxidase.
Positive_regulation (activation) of membrane in plasma
8) Confidence 0.03 Published 1980 Journal Blood Section Abstract Doc Link 6248151 Disease Relevance 0 Pain Relevance 0.09
This increase occurred via activation of plasma membrane Ca2+ channels.
Positive_regulation (activation) of membrane in plasma
9) Confidence 0.03 Published 1994 Journal Neuroreport Section Abstract Doc Link 7919177 Disease Relevance 0.09 Pain Relevance 0.21
There was a significant rise in C5b-9 membrane attack complex (P =.0012) with a corresponding fall in C3 (P =.0013) and C4 (P =.0002) levels and a rise in C3 degradation product levels (P =.0006).
Positive_regulation (rise) of membrane
10) Confidence 0.03 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.13
Dilution alone cannot explain the fall in C3 and C4 levels as there is a corresponding increase in membrane attack complex and C3 degradation product levels with time.
Positive_regulation (increase) of membrane
11) Confidence 0.03 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.09
Soluble complement receptor 1 (sCR1) was used to block the activation of the membrane attack pathway of the complement cascade.
Positive_regulation (activation) of membrane
12) Confidence 0.03 Published 2005 Journal J Pain Section Abstract Doc Link 15772911 Disease Relevance 0.64 Pain Relevance 0.53
Superoxide production by granulocytes is a result of the activation of an NAD(P)H-dependent oxidase present in the plasma membrane.
Positive_regulation (activation) of membrane in granulocytes
13) Confidence 0.02 Published 1980 Journal Blood Section Abstract Doc Link 6248151 Disease Relevance 0 Pain Relevance 0.06
Therefore the human NRL region provides the first model of an homogenous population of imidazoline-preferring, non-alpha-adrenergic membrane receptors.
Positive_regulation (population) of membrane
14) Confidence 0.02 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2721559 Disease Relevance 0 Pain Relevance 0.63
It is found either as a membrane-bound or soluble protein that is markedly upregulated by stress in epithelial cells, thereby regulating their metabolism and enhancing their central barrier functionality.
Positive_regulation (upregulated) of membrane-bound in epithelial cells associated with stress
15) Confidence 0.01 Published 2009 Journal J Transl Med Section Abstract Doc Link PMC2666642 Disease Relevance 0.72 Pain Relevance 0.20
In a very recent paper, an upregulation of TNF-related apoptosis-inducing ligand (TRAIL), a membrane-bound protein with a very close homology to TNF-?
Positive_regulation (upregulation) of membrane-bound associated with apoptosis
16) Confidence 0.01 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2452978 Disease Relevance 1.67 Pain Relevance 0.29
In our assay system the flavonol proved insensitive to target protein kinase C (PKC), as resulted from the use of PMA as basophil stimulant, thus confirming previous reports [19]: quercetin was unable to inhibit CD63 and CD203c membrane up-regulation in basophils stimulated with phorbol esters and no dissociation between the two markers investigated was actually observed by using PMA [45].
Positive_regulation (up-regulation) of membrane in basophils associated with kinase c
17) Confidence 0.01 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.27
DAG is able to activate PKC, which in turn activates membrane markers up-regulation and histamine release [39].
Positive_regulation (up-regulation) of membrane associated with kinase c
18) Confidence 0.01 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.21
The crystal structure allows a better understanding of potential disease-related epitopes, and provides clues to the functional mechanisms of P2 in lipid transport and myelin membrane stabilization.
Positive_regulation (stabilization) of membrane associated with disease
19) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858655 Disease Relevance 0.10 Pain Relevance 0.05

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