INT281470

From wiki-pain
Revision as of 14:28, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2009
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.13
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten)
nucleus (Pten) intracellular (Pten) enzyme binding (Pten)
Anatomy Link Frequency
DA neurons 2
muscle 2
Pten (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 230 100.00 Very High Very High Very High
Dynorphin 12 72.24 Quite High
Enkephalin 4 71.68 Quite High
Nucleus accumbens 2 71.68 Quite High
Eae 14 69.44 Quite High
Catecholamine 2 69.20 Quite High
midbrain 30 66.48 Quite High
Neurotransmitter 2 53.92 Quite High
5HT 2 52.88 Quite High
Substantia nigra 16 46.52 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 76 99.28 Very High Very High Very High
Hypertrophy 21 99.08 Very High Very High Very High
Targeted Disruption 26 92.52 High High
Lyme Disease 13 50.00 Quite Low
Death 20 43.72 Quite Low
Infection 6 26.04 Quite Low
INFLAMMATION 45 15.68 Low Low
Neurodegenerative Disease 12 14.32 Low Low
Obesity 1 13.36 Low Low
Cancer 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While Pten deletion does not alter DA release, it induces permanent changes in striatal postsynaptic markers
Neg (not) Regulation (alter) of Gene_expression (deletion) of Pten associated with dopamine
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.34 Pain Relevance 0.43
Moreover, the DA extraction fraction, calculated as the slope of the no net flux regression line was unchanged in KO mice, suggesting that deletion of Pten in DA neurons did not alter the clearance of extracellular DA by the DA transporter [26].
Neg (not) Regulation (alter) of Gene_expression (deletion) of Pten in DA neurons associated with dopamine
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.99
Crossing muscle specific PTEN knockouts with the AMPK?
Regulation (specific) of Gene_expression (knockouts) of PTEN in muscle
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.41 Pain Relevance 0
In this model, gene expression for phosphatase and tensin homolog (PTEN), which functions to modulate cell survival and proliferation primarily through its downstream effects on AKT1, was shown to be significantly increased (Table 6, right).
Regulation (modulate) of Gene_expression (expression) of PTEN
4) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.38 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox