INT281600

Context Info Confidence 0.05 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.66 Pain Relevance 0

mitochondrion (Casq1) Golgi apparatus (Casq1) molecular_function (Casq1) response to stress (Casq1) cytoplasm (Casq1)

Anatomy Link Frequency cardiomyocytes 1 skeletal muscle 1 Casq1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 3 5.00 ischemia 2 5.00 nalbuphine 1 5.00 Spinal cord 1 5.00 Inflammation 1 5.00 Morphine 1 5.00 analgesia 1 5.00 tolerance 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Hypoxia 52 99.84 Myocardial Infarction 6 58.56 Apoptosis 25 53.48 Lymphatic System Cancer 1 42.32 B-cell Acute Lymphoblastic Leukemia 1 41.96 Injury 16 5.00 Stress 6 5.00 Heart Rate Under Development 5 5.00 Death 4 5.00 Sepsis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, mRNA levels of Na+-Ca2+ exchanger (NCX) and calsequestrin increased in hypoxia-reoxygenated cardiomyocytes.

Positive_regulation (increased) of calsequestrin in cardiomyocytes associated with hypoxia

1) Confidence 0.05 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.66 Pain Relevance 0

Consistent with our previously reported findings [3], we observed 24 h LPS administration to result in reduced fast-twitch skeletal muscle protein content, elevated mRNA levels of MAFbx/atrogin-1 and MuRF1, and an increase in protein levels for multiple subunits of the 20S proteasome; observations that are in accordance with the reported rise in UP-mediated protein degradation during endotoxaemia in fast-twitch muscle [32].

Positive_regulation (elevated) of fast-twitch in skeletal muscle

2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0

General Comments

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