INT281922

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 20
Disease Relevance 10.45
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ARG2) small molecule metabolic process (ARG2) cellular nitrogen compound metabolic process (ARG2)
Anatomy Link Frequency
22RV1 2
ARG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 133 99.72 Very High Very High Very High
agonist 20 96.24 Very High Very High Very High
Inflammation 20 5.00 Very Low Very Low Very Low
palliative 19 5.00 Very Low Very Low Very Low
bradykinin 11 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 1026 99.84 Very High Very High Very High
Hyperplasia 76 99.36 Very High Very High Very High
Cancer 703 98.64 Very High Very High Very High
Pre-eclampsia 33 95.80 Very High Very High Very High
Malignant Neoplastic Disease 190 95.04 Very High Very High Very High
Spontaneous Abortion 1 91.84 High High
Breast Cancer 19 90.00 High High
Colon Cancer 19 88.40 High High
Toxicity 19 87.12 High High
Disease 2 66.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As arginases are well-documented to participate in the sculpting of the tumor immunological microenvironment [15] and that cytokines are known to induce arginase expression in murine models [16], we assessed whether cytokines could also regulate arginase expression in human PCa.
Positive_regulation (induce) of Gene_expression (expression) of arginase associated with cancer, reprotox - general 1 and cytokine
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.51 Pain Relevance 0.18
Since ARG2 expression is localized to mitochondria, we evaluated whether cellular proliferation independent of androgens could induce ARG2 expression in LNCaP cells.
Positive_regulation (induce) of Gene_expression (expression) of ARG2 associated with hyperplasia
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.70 Pain Relevance 0
Arginase expression and polyamine synthesis are elevated in PCa [23], [24] and associated with tumor grade [25].
Positive_regulation (elevated) of Gene_expression (expression) of Arginase associated with cancer and reprotox - general 1
3) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.92 Pain Relevance 0
There was an R1881-independant induction of PSA and ARG2 expression in LNCaP cells stimulated with 20 µM and 40 µM of bicalutamide in the absence of androgens.
Neg (independant) Positive_regulation (induction) of Gene_expression (expression) of ARG2
4) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0 Pain Relevance 0.05
Collectively, our results reveal that, although both induced by R1881, the signaling pathways leading to ARG1 and ARG2 expression differ for the two enzymes and need to be further examined.
Positive_regulation (leading) of Gene_expression (expression) of ARG2
5) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.75 Pain Relevance 0
In this report, we observed that androgens induced the expression of both ARG1 and ARG2 in HS PCa cell lines.
Positive_regulation (induced) of Gene_expression (expression) of ARG2 associated with reprotox - general 1
6) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.75 Pain Relevance 0
Following androgen stimulation of LNCaP cells with 10 nM R1881, both ARG1 and ARG2 were overexpressed.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ARG2
7) Confidence 0.69 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920336 Disease Relevance 0.99 Pain Relevance 0
Moreover, we noted that R1881 stimulation led to a decreased concentration of extracellular l-arginine, which corroborates our results demonstrating an increased arginase expression following androgen stimulation.
Positive_regulation (increased) of Gene_expression (expression) of arginase
8) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.19 Pain Relevance 0
Corroborating the PCR data, Western blots from LNCaP cells demonstrated that the R1881 stimulation increased ARG2 protein expression (Figure 2C).
Positive_regulation (increased) of Gene_expression (expression) of ARG2
9) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.12 Pain Relevance 0
IL-8 induction of ARG1 and ARG2 expression
Positive_regulation (induction) of Gene_expression (expression) of ARG2
10) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.45 Pain Relevance 0.16
The AR was implicated in this regulation as both bicalutamide and siAR transfection prevented ARG1 and ARG2 overexpression following R1881 stimulation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ARG2
11) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.75 Pain Relevance 0
These results suggest that ARG1 expression may be more sensitive to AR inhibition than ARG2, whose expression was induced by the agnostic effect of the AR inhibitor.
Positive_regulation (induced) of Gene_expression (expression) of ARG2
12) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0 Pain Relevance 0.04
It is important to note that expression of ARG1 and ARG2 following IL-8 stimulation was not as substantial as with R1881 stimulation suggesting that other androgen-regulated pathways could be involved.
Positive_regulation (stimulation) of Gene_expression (expression) of ARG2
13) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.59 Pain Relevance 0.04
The overexpression of ARG2 in 22RV1 was not statistically significant (p?
Positive_regulation (overexpression) of Gene_expression (overexpression) of ARG2 in 22RV1
14) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.27 Pain Relevance 0
Finally, we found that interleukin-8 (IL-8) was also upregulated following androgen stimulation and that it directly increased the expression of ARG1 and ARG2 in the absence of androgens.


Positive_regulation (increased) of Gene_expression (expression) of ARG2
15) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920336 Disease Relevance 0.34 Pain Relevance 0
The regulation of arginase expression following androgen stimulation was dependent on the androgen receptor (AR), as a siRNA treatment targeting the AR inhibited both ARG1 and ARG2 overexpression.
Positive_regulation (dependent) of Gene_expression (expression) of arginase
16) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920336 Disease Relevance 0.99 Pain Relevance 0
By Western blot analysis, we observed that both 50 ng/ml and 100 ng/ml of IL-8 induced the expression of ARG1 and ARG2 when compared to control LNCaP cells (Figure 5F).
Positive_regulation (induced) of Gene_expression (expression) of ARG2
17) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.15 Pain Relevance 0
The regulation of arginase expression following androgen stimulation was dependent on the androgen receptor (AR), as a siRNA treatment targeting the AR inhibited both ARG1 and ARG2 overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ARG2
18) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920336 Disease Relevance 0.94 Pain Relevance 0
Finally, we observed that IL-8 was upregulated following androgen stimulation and could induce the expression of ARG1 and ARG2.
Positive_regulation (induce) of Gene_expression (expression) of ARG2
19) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.71 Pain Relevance 0.03
They postulate that the lower normal L-arginine concentration caused by arginase II overexpression redirects eNOS toward peroxynitrite[124].


Positive_regulation (overexpression) of Gene_expression (overexpression) of arginase II
20) Confidence 0.10 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.33 Pain Relevance 0

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