INT281963

Context Info Confidence 0.12 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.24 Pain Relevance 0.26

cell differentiation (MDK) signal transduction (MDK) extracellular region (MDK) plasma membrane (SCN11A) transmembrane transport (SCN11A)

SCN11A (Homo sapiens) MDK (Homo sapiens)

Pain Link Frequency Relevance Heat dexamethasone 48 99.32 corticosteroid 8 71.48 Inflammation 2 5.00 ketamine 1 5.00 anesthesia 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 46 96.16 Bronchopulmonary Dysplasia 9 5.00 Targeted Disruption 3 5.00 Hypoxia 1 5.00 Cancer 1 5.00 Emphysema 1 5.00 Hyperglycemia 1 5.00 INFLAMMATION 1 5.00 Pneumonia 1 5.00 Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Dexamethasone treatment had a biphasic effect, increasing MK mRNA precociously, between PN1 and PN5, and then decreasing content at PN10 and PN15.

PN5 Positive_regulation (increasing) of MK associated with dexamethasone

1) Confidence 0.12 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.24 Pain Relevance 0.26

General Comments

This test has worked.