INT282090

Context Info Confidence 0.33 First Reported 2009 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.02 Pain Relevance 0

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a) protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)

Cdkn2a (Mus musculus)

Pain Link Frequency Relevance Heat palliative 1 5.00 metalloproteinase 1 5.00 fibrosis 1 5.00 Immobilon 1 5.00 Dismenorea 1 5.00

Disease Link Frequency Relevance Heat Nasopharynx Cancer 53 97.28 Aging 24 92.72 Congenital Anomalies 1 90.88 Epstein-barr Virus 6 89.00 Genetic Predisposition To Disease 1 88.80 Infection 1 87.72 Cancer 54 83.96 Lung Cancer 1 76.56 Colon Cancer 2 65.24 Stress 3 63.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Western blotting for P53, P21 and P16 proteins revealed a rapid enhancement of P53 protein followed by an increased in P21 levels, while P16 levels remained unchanged (Figure 7b).

Neg (unchanged) Regulation (unchanged) of P16

1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.59 Pain Relevance 0

Besides the LMP1-induced oncogenic pathways, dysregulation of factors such as p16, cyclin D1, and cyclin E leads to aberrations in the cell cycle in NPC cells.

Regulation (dysregulation) of p16 associated with nasopharynx cancer

2) Confidence 0.08 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.43 Pain Relevance 0

General Comments

This test has worked.