INT28243

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Context Info
Confidence 0.08
First Reported 1989
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.35
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

thd (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 80.32 Quite High
Inflammation 30 54.40 Quite High
fibrosis 3 47.32 Quite Low
cytokine 9 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 3 100.00 Very High Very High Very High
Frailty 57 87.04 High High
Disease 24 86.88 High High
Chronic Renal Failure 84 82.00 Quite High
Pancreatitis 3 80.32 Quite High
Cancer 15 60.24 Quite High
Starvation 3 59.60 Quite High
Sepsis 15 55.92 Quite High
INFLAMMATION 39 54.40 Quite High
Muscular Atrophy 12 52.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we have attempted to improve a new test: the test of haptocorrin degradation (THD).
Protein_catabolism (degradation) of THD
1) Confidence 0.08 Published 1989 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 2737391 Disease Relevance 0.08 Pain Relevance 0.08
Ubiquitin (Ub) is conjugated to proteins destined for degradation by an ATP-dependent process that involves three enzymes (E1–E3).
Protein_catabolism (degradation) of Ub
2) Confidence 0.07 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.23 Pain Relevance 0
The UPS includes concerted actions of enzymes that link ubiquitin (Ub), a member of the heat-shock protein family, to protein substrates that are destined for degradation (Fig. 1).
Protein_catabolism (degradation) of Ub associated with shock
3) Confidence 0.05 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.45 Pain Relevance 0.03
Functions of Ub not associated with proteolysis Ub can also be conjugated to proteins as a monomer (rather than as the typical Ub chain).
Neg (not) Protein_catabolism (proteolysis) of Ub
4) Confidence 0.04 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.59 Pain Relevance 0

General Comments

This test has worked.

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