INT282559

Context Info Confidence 0.14 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.45 Pain Relevance 0

DNA binding (NANOG, POU5F1) nucleus (NANOG, POU5F1) nucleoplasm (POU5F1) cell differentiation (NANOG) embryo development (NANOG) cytoplasm (POU5F1)

NANOG (Homo sapiens) POU5F1 (Homo sapiens)

Pain Link Frequency Relevance Heat Potency 8 5.00 tetrodotoxin 6 5.00 Action potential 6 5.00 Sciatic nerve 6 5.00 Hippocampus 4 5.00 anesthesia 2 5.00 withdrawal 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 14 58.32 Chromosome Aberrations 2 57.60 Death 8 55.48 Obesity 8 50.00 Stress 6 24.64 Brain Injury 6 5.00 Targeted Disruption 4 5.00 Disease 4 5.00 Teratoma 4 5.00 Adhesions 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our results showed that Oct4/ATSC can increase developmental potential following reprogramming via the overexpression of the embryonic transcription factors, Rex1, Oct4, and Oct4-dependent Nanog and Sox2.

Nanog Regulation (dependent) of Oct4

1) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.23 Pain Relevance 0

Our results showed that Oct4/ATSC can increase developmental potential following reprogramming via the overexpression of the embryonic transcription factors, Rex1, Oct4, and Oct4-dependent Nanog and Sox2.

Nanog Regulation (dependent) of Oct4

2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.23 Pain Relevance 0

General Comments

This test has worked.