INT282636

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nmt1) transferase activity, transferring acyl groups (Nmt1) cellular_component (Nmt1)
biological_process (Nmt1) cytoplasm (Nmt1)
Anatomy Link Frequency
neurons 1
Nmt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 6 98.62 Very High Very High Very High
Glutamate receptor 1 94.84 High High
gABA 3 93.80 High High
Potency 2 70.00 Quite High
Central nervous system 3 59.76 Quite High
anticonvulsant 1 41.80 Quite Low
sodium channel 1 34.48 Quite Low
carbamazepine 6 27.56 Quite Low
headache 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 53 79.92 Quite High
Epilepsy 28 77.16 Quite High
Shock 2 46.20 Quite Low
Targeted Disruption 1 15.28 Low Low
Anxiety 6 5.00 Very Low Very Low Very Low
Dizziness 6 5.00 Very Low Very Low Very Low
Generalized Epilepsy 5 5.00 Very Low Very Low Very Low
Learning Disorders 4 5.00 Very Low Very Low Very Low
Headache 4 5.00 Very Low Very Low Very Low
Sleep Disorders 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levetiracetam has no inhibitory effect on sodium or low-voltage-activated, T-type calcium channels in rat neocortical neurons12 and does not have a high affinity for GABA, N-methyl d-aspartate (NMDA) or glutamate receptors.6,7,11 Levetiracetam reduces high-voltage, N-type, calcium channel currents in isolated rat CA1 hippocampal neurons but does not have an effect on L-type, P-type or Q-type calcium channels.13,14 This effect occurs within a few seconds and suggests a direct interaction of levetiracetam with the N-type channel, rather than a second messenger pathway.
N-type Binding (interaction) of in neurons associated with gaba, glutamate receptor and calcium channel
1) Confidence 0.01 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2747386 Disease Relevance 0.27 Pain Relevance 0.37

General Comments

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