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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2011
Negated 4
Speculated 3
Reported most in Abstract
Documents 62
Total Number 65
Disease Relevance 29.10
Pain Relevance 41.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) extracellular region (Calca) nucleus (Calca)
intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
sensory neurons 5
skin 3
neurons 3
trigeminal ganglion 2
fat 2
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 347 100.00 Very High Very High Very High
Calcitonin gene-related peptide 346 100.00 Very High Very High Very High
Inflammation 159 100.00 Very High Very High Very High
substance P 71 100.00 Very High Very High Very High
Neuropeptide 62 100.00 Very High Very High Very High
dorsal root ganglion 58 100.00 Very High Very High Very High
bradykinin 37 100.00 Very High Very High Very High
calcitonin gene related peptide 34 100.00 Very High Very High Very High
Central nervous system 9 100.00 Very High Very High Very High
Analgesic 37 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 77 100.00 Very High Very High Very High
Neurogenic Inflammation 15 100.00 Very High Very High Very High
Targeted Disruption 72 99.96 Very High Very High Very High
Inflammatory Pain 10 99.96 Very High Very High Very High
Dysmenorrhea 1 99.84 Very High Very High Very High
Hyperalgesia 38 99.76 Very High Very High Very High
Photophobia 5 99.68 Very High Very High Very High
Schistosomiasis Mansoni 2 99.68 Very High Very High Very High
Injury 54 99.56 Very High Very High Very High
Pruritus 89 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This RTX-induced increase in CGRP immunoreactivity was completely blocked by Ruthenium red (RR).
Positive_regulation (increase) of CGRP associated with calcitonin gene-related peptide
1) Confidence 0.70 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7955356 Disease Relevance 0.33 Pain Relevance 0.84
Significant increases of the hippocampal tissue levels of CGRP, IGF-I, and IGF-I messenger RNA (mRNA) were observed after capsaicin administration in WT mice (P < 0.01) but not in CGRP-/- mice.
Positive_regulation (increases) of CGRP associated with qutenza and calcitonin gene-related peptide
2) Confidence 0.69 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.52 Pain Relevance 1.01
Activation of CGRP1 receptors or NK(1)+NK(2) receptors participate in granulocyte accumulation, but NK(2) receptors play predominant role in enhanced airway resistance.
Positive_regulation (Activation) of CGRP in granulocyte
3) Confidence 0.67 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17291600 Disease Relevance 0.47 Pain Relevance 0.74
CGRP and p75 NTR immunoreactivity in the L5 DRG neurons was upregulated in the injured nerve groups compared with the sham-operated group; however, p75 NTR inhibitory antibody decreased the CGRP and p75 NTR expression (p < 0.01).
Positive_regulation (upregulated) of CGRP in nerve associated with calcitonin gene-related peptide
4) Confidence 0.66 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19824062 Disease Relevance 0.57 Pain Relevance 1.04
Substance P and calcitonin gene-related peptide were up-regulated on Day 18 but down-regulated on Day 25.
Positive_regulation (up-regulated) of calcitonin associated with calcitonin gene-related peptide and substance p
5) Confidence 0.63 Published 2005 Journal Pain Section Abstract Doc Link 15733648 Disease Relevance 0.72 Pain Relevance 0.92
These observations strongly suggest that the stimulation of sensory neurons by capsaicin might increase IGF-I production via increasing the hippocampal tissue CGRP levels, and it may thereby promote angiogenesis and neurogenesis to produce improvement of the cognitive function in mice.
Spec (might) Positive_regulation (increase) of CGRP in sensory neurons associated with cognitive disorder, qutenza, neurodegenerative disease and calcitonin gene-related peptide
6) Confidence 0.60 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.46 Pain Relevance 1.18
We first demonstrated that activation of CGRP receptors on cultured trigeminal ganglion neurons increased endogenous CGRP mRNA levels and promoter activity.
Positive_regulation (activation) of CGRP in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion neurons and calcitonin gene-related peptide
7) Confidence 0.58 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17344407 Disease Relevance 0.42 Pain Relevance 0.62
In this model system, TNF-alpha in the NP appears to mediate pain, but not cause an increase in CGRP in the DRG neurons.


Positive_regulation (increase) of CGRP in DRG
8) Confidence 0.52 Published 2008 Journal Spine Section Body Doc Link 18670336 Disease Relevance 0 Pain Relevance 0
A variety of neurochemical markers that have been implicated in the generation and maintenance of chronic pain were then examined in spinal cord and primary afferent neurons.Three days after injection of complete Freund's adjuvant into the hindpaw (a model of persistent inflammatory pain) increases in substance P, calcitonin gene-related peptide, protein kinase C gamma, and substance P receptor were observed in the spinal cord.
Positive_regulation (increases) of calcitonin in spinal cord associated with kinase c, ipn, lasting pain, calcitonin gene-related peptide, substance p and spinal cord
9) Confidence 0.50 Published 2000 Journal Neuroscience Section Abstract Doc Link 10869852 Disease Relevance 1.05 Pain Relevance 1.44
The analgesic effect of calcitonin when serotonin (5-HT) concentration is increased and the involvement of some 5-HT receptors were studied using the writhing test in mice. 5-hydroxytryptophan (5-HTP) administration increased both 5-HT levels in the central nervous system (CNS) and calcitonin analgesia.
Positive_regulation (increased) of calcitonin in central nervous system associated with analgesic, central nervous system, serotonin and analgesia
10) Confidence 0.50 Published 1999 Journal Brain Res. Section Abstract Doc Link 10536192 Disease Relevance 0 Pain Relevance 0.84
The 5-HT(3) agonist (+/-)-2-methyl-5-hydroxytryptamine maleate (2-methyl-5-HT) potentiated calcitonin analgesia, whereas it was significantly reduced by the 5-HT(3) antagonist tropisetron.
Positive_regulation (potentiated) of calcitonin associated with antagonist, agonist and analgesia
11) Confidence 0.50 Published 1999 Journal Brain Res. Section Abstract Doc Link 10536192 Disease Relevance 0 Pain Relevance 1.16
The increased CGRP immunoreactivity was observed both in the axonal varicosities and in the perinuclear region of cell bodies.
Positive_regulation (increased) of CGRP associated with increased venous pressure under development and calcitonin gene-related peptide
12) Confidence 0.50 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7955356 Disease Relevance 0.33 Pain Relevance 0.76
Capsaicin, bradykinin and the potassium solution caused concentration-dependent increases in CGRP release.
Positive_regulation (increases) of CGRP associated with qutenza, bradykinin and calcitonin gene-related peptide
13) Confidence 0.50 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16413055 Disease Relevance 0.13 Pain Relevance 0.82
CAP stimulation induced a significant CGRP release, which, however, did not correlate with the temporal development of OA in STR/1N mice.
Positive_regulation (induced) of CGRP
14) Confidence 0.50 Published 2004 Journal J. Rheumatol. Section Body Doc Link 15468368 Disease Relevance 0.06 Pain Relevance 0
In addition, a double in situ hybridization technique demonstrated the intense expression of calcitonin receptor mRNA on serotonergic neurons in some raphe nuclei and the lateral paragigantocellular nucleus, suggesting the involvement of central serotonergic pathways in analgesic effect of calcitonin.
Positive_regulation (effect) of calcitonin in lateral associated with analgesic and raphe
15) Confidence 0.50 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10719219 Disease Relevance 0.17 Pain Relevance 0.54
The present study was undertaken to examine if nitric oxide (NO) production by nitric oxide synthase (NOS) isoforms mediates the inhibitory action of CGRP on uterine contractions as has been suggested earlier.
Spec (examine) Positive_regulation (mediates) of CGRP in uterine associated with dismenorea and calcitonin gene-related peptide
16) Confidence 0.49 Published 2000 Journal Biol. Reprod. Section Abstract Doc Link 11058547 Disease Relevance 0.20 Pain Relevance 0.43
Fifty percent ethanol containing capsaicin immediately increased intragastric levels of CGRP in wild-type (WT) mice, although 50% ethanol alone did not.
Positive_regulation (increased) of CGRP
17) Confidence 0.47 Published 2008 Journal Gastroenterology Section Body Doc Link 18054007 Disease Relevance 0.24 Pain Relevance 0
Intragastric perfusion of 50% ethanol after administration of PGI(2), but not of PGE(2), increased CGRP levels.
Positive_regulation (increased) of CGRP
18) Confidence 0.46 Published 2001 Journal Gastroenterology Section Body Doc Link 11208722 Disease Relevance 0.07 Pain Relevance 0
CGRP level during ethanol perfusion was not increased in IP(-/-) but was increased in EP3(-/-) and wild-type counterparts after preperfusion of 1 mol/L NaCl.
Neg (not) Positive_regulation (increased) of CGRP
19) Confidence 0.46 Published 2001 Journal Gastroenterology Section Body Doc Link 11208722 Disease Relevance 0.06 Pain Relevance 0
CGRP level during ethanol perfusion was not increased in IP(-/-) but was increased in EP3(-/-) and wild-type counterparts after preperfusion of 1 mol/L NaCl.
Neg (not) Positive_regulation (increased) of CGRP
20) Confidence 0.46 Published 2001 Journal Gastroenterology Section Body Doc Link 11208722 Disease Relevance 0.06 Pain Relevance 0

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