INT282985

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.72
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Becn1) cytoplasmic membrane-bounded vesicle (Becn1) cytoskeleton (Becn1)
cell cycle (Becn1) cell division (Becn1) protein complex (Becn1)
Anatomy Link Frequency
neuronal 1
body 1
Becn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 12 78.96 Quite High
anesthesia 10 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
halothane 8 5.00 Very Low Very Low Very Low
Limbic system 6 5.00 Very Low Very Low Very Low
Substantia nigra 3 5.00 Very Low Very Low Very Low
Locus ceruleus 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 141 99.68 Very High Very High Very High
Alzheimer's Dementia 18 99.56 Very High Very High Very High
Targeted Disruption 32 99.44 Very High Very High Very High
Infection 419 99.32 Very High Very High Very High
Neurodegenerative Disease 34 99.32 Very High Very High Very High
Togavirus Infection 8 98.88 Very High Very High Very High
Apoptosis 837 98.40 Very High Very High Very High
Parkinson's Disease 127 97.80 Very High Very High Very High
Dementia 19 96.80 Very High Very High Very High
Neurological Disease 4 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, previous studies have shown that in sporadic AD there is a profound reduction in the levels of Beclin-1 [34], while the neurodegenerative process in familial forms of fronto-temporal dementia and ALS has been linked to mutations in charged multivesicular body protein-2B (CHMP2B) [86], [87], [88], and in Huntington's Disease polyglutamate aggregates trap mTor and disrupt autophagy [80].
Negative_regulation (reduction) of Beclin-1 in body associated with dementia, neurodegenerative disease and disease
1) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.19 Pain Relevance 0
Consistent with previous studies [34], levels of Beclin-1 in the membrane fractions were reduced in the AD cases compared to non-demented controls and DLB, however no differences in Beclin-1 levels were detected between non-demented controls and DLB cases (Figure 1A, C).
Negative_regulation (reduced) of Beclin-1 associated with parkinson's disease and disease
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.91 Pain Relevance 0.04
Genetic manipulations that decrease Beclin 1 levels in AD transgenic mice reduce neuronal autophagy, disrupt lysosomes, promote intracellular and extracellular A?
Negative_regulation (decrease) of Beclin 1 in neuronal associated with targeted disruption and alzheimer's dementia
3) Confidence 0.08 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 1.58 Pain Relevance 0
Similarly, depletion of beclin1 in plants aggravates the tobacco mosaic virus-induced hypersensitive response (HR) [8].
Negative_regulation (depletion) of beclin1
4) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.72 Pain Relevance 0
We show that removing the BH2 domain from vBcl-2 does not affect vBcl-2's capacity to bind and suppress Beclin1, but it significantly dampens its anti-apoptotic activity.
Neg (not) Negative_regulation (suppress) of Beclin1 associated with apoptosis
5) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.71 Pain Relevance 0
Given the pivotal role of vBcl-2 in apoptosis inhibition, it is important to know if the regions of vBcl-2, which is required for binding and inhibiting Beclin1, are equally or differentially required for blocking apoptosis.
Negative_regulation (inhibiting) of Beclin1 associated with apoptosis
6) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.62 Pain Relevance 0
In fact, the anti-autophagic action of Bcl-2 closely mirrors its capacity to bind and inhibit Beclin1 [12].
Negative_regulation (inhibit) of Beclin1
7) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.71 Pain Relevance 0
HV68 infection can trigger cellular autophagy, which is antagonized by vBcl-2 through Beclin1 inhibition.
Negative_regulation (inhibition) of Beclin1 associated with infection
8) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.30 Pain Relevance 0
1 helix leads to the loss of both Beclin1 binding and autophagy suppressing activity, reflecting a striking correlation between the ability of vBcl-2 to bind Beclin1 and its protection from Beclin1-mediated autophagy.
Negative_regulation (loss) of Beclin1
9) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0 Pain Relevance 0
We found that a Beclin1-binding-deficient vBcl-2 mutant virus, which is impaired in autophagy inhibition but retains intact anti-apoptotic activity, was compromised in the maintenance of latency, though the initial viral establishment of latency was unaffected.
Negative_regulation (impaired) of Beclin1-binding associated with apoptosis
10) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.98 Pain Relevance 0
1 helix but not the BH2 domain abolished endogenous Beclin1 binding (Figure 2B).
Negative_regulation (abolished) of Beclin1
11) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0 Pain Relevance 0

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