INT283043

From wiki-pain
Revision as of 21:37, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.17
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.67
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbpl1) DNA binding (Tbpl1) cytoplasm (Tbpl1)
Anatomy Link Frequency
neuronal 2
ganglia 2
Tbpl1 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 15 100.00 Very High Very High Very High
Neuronal excitability 1 98.52 Very High Very High Very High
Neuropathic pain 43 93.52 High High
allodynia 61 90.92 High High
dorsal root ganglion 24 86.24 High High
Eae 30 73.60 Quite High
agonist 14 67.44 Quite High
Inflammation 17 66.24 Quite High
calcitonin gene related peptide 12 56.04 Quite High
Hyperalgesia 17 50.00 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 50 99.92 Very High Very High Very High
Hodgkin's Disease 231 99.84 Very High Very High Very High
Lymphatic System Cancer 75 99.12 Very High Very High Very High
Injury 135 98.84 Very High Very High Very High
Hypersensitivity 25 95.12 Very High Very High Very High
Neuropathic Pain 126 93.52 High High
Ganglion Cysts 48 86.24 High High
Drug Induced Neurotoxicity 3 77.76 Quite High
INFLAMMATION 18 66.24 Quite High
Inflammatory Pain 8 62.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With prolonged drug exposure, sustained increase of the TRP transcripts expression may result from increased long-term neuronal excitability.
Positive_regulation (increase) of Gene_expression (expression) of TRP in neuronal associated with neuronal excitability
1) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.43 Pain Relevance 0.27
However, in agreement with our results in mice, we were unable to detect an upregulation in TRP channel expression in either ganglia following injury.
Neg (unable) Positive_regulation (upregulation) of Gene_expression (expression) of TRP in ganglia associated with trp channel and injury
2) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.74 Pain Relevance 0.30
TRP channel expression remains constant for a period of hours after dissociation [29], therefore all experiments were performed within 3 hours of plating cells.
Positive_regulation (constant) of Gene_expression (expression) of TRP associated with trp channel
3) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.57 Pain Relevance 0.27
We have previously reported a novel constitutively overexpressed 21 kDa protein in Hodgkin Lymphoma (HL) and aggressive Non-Hodgkin Lymphomas (NHL).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of 21 kDa protein associated with lymphatic system cancer and hodgkin's disease
4) Confidence 0.01 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2829491 Disease Relevance 0.66 Pain Relevance 0
Constitutively overexpressed 21 kDa protein in Hodgkin lymphoma and aggressive non-Hodgkin lymphomas identified as cytochrome B5b (CYB5B)

Background

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of 21 kDa protein associated with lymphatic system cancer and hodgkin's disease
5) Confidence 0.01 Published 2010 Journal Mol Cancer Section Title Doc Link PMC2829491 Disease Relevance 0.99 Pain Relevance 0
The 21 kDa protein overexpressed in HL and aggressive NHL is identical to CYB5B.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of 21 kDa protein associated with lymphatic system cancer and hodgkin's disease
6) Confidence 0.01 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2829491 Disease Relevance 1.28 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox