INT283110

Context Info Confidence 0.73 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 3.14 Pain Relevance 0.61

nucleoplasm (Dag1) extracellular space (Dag1) extracellular region (Dag1) plasma membrane (Dag1) cytoskeleton (Dag1) nucleus (Dag1)

Anatomy Link Frequency blood vessels 1 astrocytes 1 synapse 1 Dag1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory mediators 15 97.08 potassium channel 21 94.28 adenocard 15 82.56 addiction 3 54.60 Central nervous system 8 37.08 Neurotransmitter 30 27.24 Inflammation 14 5.00 Hippocampus 13 5.00 Spinal cord 10 5.00 ischemia 9 5.00

Disease Link Frequency Relevance Heat Alzheimer's Dementia 6 99.66 Pressure And Volume Under Development 60 99.12 INFLAMMATION 29 97.08 Cerebral Amyloid Angiopathy 5 89.40 Targeted Disruption 26 88.24 Muscular Dystrophy 52 83.92 Stress 14 83.44 Disease 80 82.08 Congenital Anomalies 14 79.20 Night Blindness 1 76.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Second, Dp71 immunoreactivity is localized in Müller cell endfeet and processes surrounding retinal blood vessels [14] (Fig.

Localization (localized) of Dp71 in blood vessels

1) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.48 Pain Relevance 0.22

These data suggest that deletion of Dp71 modifies the osmotic swelling characteristics of Müller cells, and that inflammatory mediators are involved in this alteration.

Localization (deletion) of Dp71 associated with pressure and volume under development and inflammatory mediators

2) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.72 Pain Relevance 0.28

These alterations are associated with a strong decrease of Dp71, a cytoskeleton protein responsible for the localization and the clustering of Kir4.1 and AQP4.

Localization (localization) of Dp71

3) Confidence 0.73 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2754330 Disease Relevance 0.32 Pain Relevance 0.09

At the ribbon synapse, Dp260, Dp140, and Dp71, as well as ?

Localization (well) of Dp71 in synapse

4) Confidence 0.47 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.37 Pain Relevance 0

A potential explanation for the loss of AQP4 and Kir4.1 channels is that they share a common anchoring protein that is affected by vascular amyloid deposition: the Dp71 dystrophin protein, localized on perivascular astrocytes [40].

Localization (localized) of Dp71 in astrocytes associated with alzheimer's dementia

5) Confidence 0.24 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.24 Pain Relevance 0.03

General Comments

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