INT283202

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DMD) cytoskeleton (DMD) nucleus (DMD)
molecular_function (Gm4658) cellular_component (Gm4658) cytoplasm (DMD)
Anatomy Link Frequency
muscles 2
Gm4658 (Mus musculus)
DMD (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 2 56.72 Quite High
beta blocker 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Dystrophy 86 98.44 Very High Very High Very High
Fibrosis 2 56.72 Quite High
Disease 2 25.00 Low Low
Duchenne Muscular Dystrophy 8 5.00 Very Low Very Low Very Low
Respiratory Failure 4 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Coronary Heart Disease 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed, in vivo, that the PMO AVI-4658 induced specific skipping of exon 51 and the production of dystrophin that was correctly localised at the sarcolemma.
PMO AVI-4658 Positive_regulation (induced) of Gene_expression (production) of dystrophin
1) Confidence 0.01 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0.25 Pain Relevance 0.03
Intramuscular AVI-4658 was safe and induced the expression of dystrophin locally within treated muscles.
AVI-4658 Positive_regulation (induced) of Gene_expression (expression) of dystrophin in muscles
2) Confidence 0.01 Published 2009 Journal Lancet Neurol Section Abstract Doc Link PMC2755039 Disease Relevance 0.07 Pain Relevance 0

General Comments

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