INT284047

Context Info Confidence 0.05 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.68 Pain Relevance 0.30

extracellular space (Ighg2b) plasma membrane (Vtcn1) cellular_component (Vtcn1)

Anatomy Link Frequency CII 2 Vtcn1 (Mus musculus) Ighg2b (Mus musculus)

Pain Link Frequency Relevance Heat Arthritis 87 98.76 agonist 8 73.20 Inflammation 24 72.32 rheumatoid arthritis 75 5.00 cytokine 5 5.00 Inflammatory response 4 5.00 chemokine 2 5.00 Lasting pain 1 5.00 Freund adjuvant 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat Arthritis 84 98.76 Immunization 14 89.48 Pressure And Volume Under Development 8 76.40 INFLAMMATION 28 72.32 Autoimmune Disease 18 59.08 Rheumatoid Arthritis 77 50.00 Disease 33 5.00 Disease Progression 7 5.00 Erythema 5 5.00 Targeted Disruption 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, B7-H4Ig plasmid treatment suppressed the production of total IgG (Figure 5C) and IgG1, IgG2a, and IgG2b autoantibodies to CII (Figure S7).

B7-H4Ig Negative_regulation (suppressed) of Gene_expression (production) of IgG2b in CII

1) Confidence 0.05 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.68 Pain Relevance 0.30

General Comments

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