INT284059

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Context Info
Confidence 0.22
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 5.18
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
arms 3
placenta 2
Vsnl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antiemetics 18 99.80 Very High Very High Very High
Antihistamine 18 98.46 Very High Very High Very High
antagonist 15 69.52 Quite High
Dopamine 3 40.00 Quite Low
abdominal pain 3 10.96 Low Low
corticosteroid 9 5.00 Very Low Very Low Very Low
nud 9 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
transdermal 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vomiting 186 99.80 Very High Very High Very High
Hyperemesis Gravidarum 42 97.44 Very High Very High Very High
Congenital Anomalies 6 85.84 High High
Birth Weight 9 84.12 Quite High
Weight Loss 9 83.96 Quite High
Adverse Drug Reaction 3 82.44 Quite High
Sleep Disorders 6 82.40 Quite High
Fatigue 6 81.32 Quite High
Sepsis 3 76.24 Quite High
Infection 27 71.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Generally it has been observed that women who experience NVP have better pregnancy outcomes than those who don’t, and women who use antiemetics appear to have better pregnancy outcomes than women with NVP who don’t receive treatment.10 One explanation for this is that women who use antiemetics, tend to experience severe NVP which may be associated with a more robust placenta secreting high levels of hCG hormones; thus the better outcome for the antiemetic group of women could be attributed to the placenta itself and not so much the therapy.10
Positive_regulation (experience) of NVP in placenta associated with vomiting and antiemetics
1) Confidence 0.22 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990891 Disease Relevance 0.97 Pain Relevance 0.10
Other H1-blocker antihistamines such as dimenhydrinate (Gravol®) and diphenhydramine (Benadryl®), have been used for NVP treatment without safety concerns.
Positive_regulation (used) of NVP associated with antihistamine
2) Confidence 0.22 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990891 Disease Relevance 0.82 Pain Relevance 0.19
Generally it has been observed that women who experience NVP have better pregnancy outcomes than those who don’t, and women who use antiemetics appear to have better pregnancy outcomes than women with NVP who don’t receive treatment.10 One explanation for this is that women who use antiemetics, tend to experience severe NVP which may be associated with a more robust placenta secreting high levels of hCG hormones; thus the better outcome for the antiemetic group of women could be attributed to the placenta itself and not so much the therapy.10
Positive_regulation (experience) of NVP in placenta associated with vomiting and antiemetics
3) Confidence 0.22 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990891 Disease Relevance 1.09 Pain Relevance 0.09
The most common abnormal laboratory tests were below normal haemoglobin and above normal aspartate aminotransferase (AST) levels; there were 24, 55, and 56 women in the NVP, NVP/CBV4, and NVP/CBV7 arms, respectively, whose AST levels were elevated above normal.
Positive_regulation (elevated) of NVP in arms
4) Confidence 0.01 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.77 Pain Relevance 0
The most common abnormal laboratory tests were below normal haemoglobin and above normal aspartate aminotransferase (AST) levels; there were 24, 55, and 56 women in the NVP, NVP/CBV4, and NVP/CBV7 arms, respectively, whose AST levels were elevated above normal.
Positive_regulation (elevated) of NVP in arms
5) Confidence 0.01 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.76 Pain Relevance 0
The most common abnormal laboratory tests were below normal haemoglobin and above normal aspartate aminotransferase (AST) levels; there were 24, 55, and 56 women in the NVP, NVP/CBV4, and NVP/CBV7 arms, respectively, whose AST levels were elevated above normal.
Positive_regulation (elevated) of NVP in arms
6) Confidence 0.00 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760761 Disease Relevance 0.77 Pain Relevance 0

General Comments

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