INT284669

Context Info Confidence 0.65 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 6 Disease Relevance 4.58 Pain Relevance 1.14

mitochondrion (LRRK2) plasma membrane (LRRK2) intracellular (LRRK2) GTPase activity (LRRK2) cytoplasm (LRRK2)

Anatomy Link Frequency neuronal 1 dopaminergic neurons 1 LRRK2 (Homo sapiens)

Pain Link Frequency Relevance Heat spinal inflammation 164 80.72 spondylitis 8 75.00 psoriasis 16 72.32 Crohn's disease 60 66.24 Inflammation 36 47.16 Arthritis 8 34.64 rheumatoid arthritis 16 5.00 Glutamate 8 5.00 Multiple sclerosis 6 5.00 addiction 6 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 144 99.98 Toxicity 128 99.12 Helminth Infection 144 98.86 Disease 232 91.32 Inflammatory Bowel Disease 100 88.08 Ankylosing Spondylitis 168 80.96 Diabetes Mellitus 20 76.32 Psoriasis 16 72.32 Creutzfeldt Jakob Disease 4 69.84 Kuru 2 69.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

0.82 (95% CI:0.74–0.91)), LRRK2/MUC19 (rs11175593, P?

Gene_expression (/) of LRRK2

1) Confidence 0.65 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2996314 Disease Relevance 0.85 Pain Relevance 0.41

0.82 (95% CI:0.74–0.91)), LRRK2/MUC19 (rs11175593, P?

Gene_expression (rs11175593) of LRRK2

2) Confidence 0.65 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2996314 Disease Relevance 0.85 Pain Relevance 0.42

0.83 (95% CI:0.76–0.91)), LRRK2/MUC19 (rs11175593, P?

Gene_expression (/) of LRRK2

3) Confidence 0.65 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 0.50 Pain Relevance 0.16

0.83 (95% CI:0.76–0.91)), LRRK2/MUC19 (rs11175593, P?

Gene_expression (rs11175593) of LRRK2

4) Confidence 0.65 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 0.51 Pain Relevance 0.16

However, transgenic LRRK2 expression also led to a preferential loss of dopaminergic neurons, with G2019S fPD LRRK2 being measurably more toxic than wild type LRRK2.

Gene_expression (expression) of LRRK2 in dopaminergic neurons associated with targeted disruption

5) Confidence 0.24 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2762972 Disease Relevance 0.86 Pain Relevance 0

Saha et al [63] have recently shown that knockdown of lrk-1 sensitizes worms to the mitochondrial toxic rotenone, while pan-neuronal expression of wild type human or G2019S fPD LRRK2 (driven by the snb-1 promoter) protects against rotenone toxicity.

Gene_expression (expression) of LRRK2 in neuronal associated with toxicity and helminth infection

6) Confidence 0.21 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2762972 Disease Relevance 1.01 Pain Relevance 0

General Comments

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